MIR4776-1

Summary

MIR4776-1 (microRNA 4776-1, HGNC:41641) is a microRNA gene on chromosome 2q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616267 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41641
Approved symbol	MIR4776-1
Name	microRNA 4776-1
Location	2q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4776-1
Ensembl gene	ENSG00000266354
Ensembl biotype	miRNA
Entrez	100616267
RNAcentral	URS000075DB0F — miRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580204

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580204 — 1 exons

Exon	Start	End
ENSE00002720078	212926257	212926336

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 73.06.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.06	gold quality
islet of Langerhans	UBERON:0000006	65.27	gold quality
gastrocnemius	UBERON:0001388	64.94	gold quality
skin of leg	UBERON:0001511	54.52	gold quality
vagina	UBERON:0000996	53.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.66	gold quality
cerebellar hemisphere	UBERON:0002245	51.60	gold quality
tibial nerve	UBERON:0001323	50.47	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.17	gold quality
esophagus mucosa	UBERON:0002469	49.72	gold quality
left lobe of thyroid gland	UBERON:0001120	48.05	gold quality
pituitary gland	UBERON:0000007	47.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. (PMID:28448456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.