MIR4777

Summary

MIR4777 (microRNA 4777, HGNC:41773) is a microRNA gene on chromosome 2q37.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616317 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41773
Approved symbol	MIR4777
Name	microRNA 4777
Location	2q37.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4777
Ensembl gene	ENSG00000263641
Ensembl biotype	miRNA
Entrez	100616317
RNAcentral	URS000075C108 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583710

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583710 — 1 exons

Exon	Start	End
ENSE00002716852	231362708	231362793

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 79.05.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	79.05	gold quality
blood	UBERON:0000178	76.32	gold quality
fundus of stomach	UBERON:0001160	75.73	gold quality
endometrium	UBERON:0001295	72.98	gold quality
right lobe of liver	UBERON:0001114	72.93	gold quality
gastrocnemius	UBERON:0001388	72.82	gold quality
right atrium auricular region	UBERON:0006631	71.87	gold quality
islet of Langerhans	UBERON:0000006	71.33	gold quality
monocyte	CL:0000576	71.05	gold quality
stomach	UBERON:0000945	70.98	gold quality
gall bladder	UBERON:0002110	69.99	gold quality
tibial artery	UBERON:0007610	69.82	gold quality
body of stomach	UBERON:0001161	69.69	gold quality
adrenal gland	UBERON:0002369	69.28	gold quality
heart	UBERON:0000948	69.17	gold quality
body of pancreas	UBERON:0001150	69.16	gold quality
liver	UBERON:0002107	69.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.90	gold quality
putamen	UBERON:0001874	68.60	gold quality
Ammon’s horn	UBERON:0001954	68.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.36	gold quality
lower esophagus	UBERON:0013473	68.35	gold quality
amygdala	UBERON:0001876	68.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.42	gold quality
heart left ventricle	UBERON:0002084	67.34	gold quality
left adrenal gland	UBERON:0001234	67.30	gold quality
intestine	UBERON:0000160	67.04	gold quality
ascending aorta	UBERON:0001496	66.82	gold quality
left adrenal gland cortex	UBERON:0035825	66.82	gold quality
thoracic aorta	UBERON:0001515	66.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.