MIR4778

Summary

MIR4778 (microRNA 4778, HGNC:41648) is a microRNA gene on chromosome 2p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616464 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41648
Approved symbol	MIR4778
Name	microRNA 4778
Location	2p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4778
Ensembl gene	ENSG00000264525
Ensembl biotype	miRNA
Entrez	100616464
RNAcentral	URS000075D462 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577635

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577635 — 1 exons

Exon	Start	End
ENSE00002711775	66358249	66358328

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 75.13.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	75.13	gold quality
endometrium	UBERON:0001295	75.06	gold quality
monocyte	CL:0000576	72.77	gold quality
fundus of stomach	UBERON:0001160	71.99	gold quality
adipose tissue	UBERON:0001013	71.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.53	gold quality
blood	UBERON:0000178	69.92	gold quality
vagina	UBERON:0000996	67.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.46	gold quality
stomach	UBERON:0000945	66.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.45	gold quality
transverse colon	UBERON:0001157	64.95	gold quality
esophagus mucosa	UBERON:0002469	64.33	gold quality
skin of leg	UBERON:0001511	64.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.26	gold quality
minor salivary gland	UBERON:0001830	62.58	gold quality
putamen	UBERON:0001874	62.33	gold quality
spleen	UBERON:0002106	60.88	gold quality
tibial nerve	UBERON:0001323	60.34	gold quality
prostate gland	UBERON:0002367	59.81	gold quality
skin of abdomen	UBERON:0001416	59.35	gold quality
nucleus accumbens	UBERON:0001882	57.97	gold quality
anterior cingulate cortex	UBERON:0009835	54.99	gold quality
right testis	UBERON:0004534	44.19	gold quality
testis	UBERON:0000473	43.12	gold quality
left testis	UBERON:0004533	42.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.