MIR4779

Summary

MIR4779 (microRNA 4779, HGNC:41747) is a microRNA gene on chromosome 2p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616159 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41747
Approved symbol	MIR4779
Name	microRNA 4779
Location	2p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4779
Ensembl gene	ENSG00000265420
Ensembl biotype	miRNA
Entrez	100616159
RNAcentral	URS000075AE20 — ncRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579234

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579234 — 1 exons

Exon	Start	End
ENSE00002711424	86193026	86193108

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 77.27.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.27	gold quality
endometrium	UBERON:0001295	76.30	gold quality
adrenal tissue	UBERON:0018303	73.61	gold quality
gastrocnemius	UBERON:0001388	71.80	gold quality
monocyte	CL:0000576	71.40	gold quality
adult mammalian kidney	UBERON:0000082	71.18	gold quality
vagina	UBERON:0000996	70.57	gold quality
stomach	UBERON:0000945	70.20	gold quality
heart	UBERON:0000948	68.55	gold quality
body of stomach	UBERON:0001161	67.98	gold quality
liver	UBERON:0002107	67.48	gold quality
heart left ventricle	UBERON:0002084	67.17	gold quality
tibial artery	UBERON:0007610	67.15	gold quality
transverse colon	UBERON:0001157	67.14	gold quality
apex of heart	UBERON:0002098	66.94	gold quality
ascending aorta	UBERON:0001496	66.83	gold quality
myometrium	UBERON:0001296	66.35	gold quality
hypothalamus	UBERON:0001898	66.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.42	gold quality
body of pancreas	UBERON:0001150	65.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.27	gold quality
right testis	UBERON:0004534	64.17	gold quality
esophagus mucosa	UBERON:0002469	63.84	gold quality
minor salivary gland	UBERON:0001830	63.52	gold quality
left uterine tube	UBERON:0001303	63.17	gold quality
omental fat pad	UBERON:0010414	63.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.04	gold quality
pituitary gland	UBERON:0000007	63.00	gold quality
right lobe of thyroid gland	UBERON:0001119	62.58	gold quality
skin of abdomen	UBERON:0001416	62.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The novel tumor suppressor miR-4779 inhibits cancer cell growth via cell cycle arrest and apoptosis by directly targeting PAK2 and CCND3. (PMID:29362401)
• PLK1 Knockdown Inhibits Cell Proliferation and Cell Apoptosis, and PLK1 Is Negatively Regulated by miR-4779 in Osteosarcoma Cells (PMID:32182129)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.