MIR4780

Summary

MIR4780 (microRNA 4780, HGNC:41552) is a microRNA gene on chromosome 2p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616447 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41552
Approved symbol	MIR4780
Name	microRNA 4780
Location	2p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4780
Ensembl gene	ENSG00000265003
Ensembl biotype	miRNA
Entrez	100616447
RNAcentral	URS0000759DBF — ncRNA, 81 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584268

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584268 — 1 exons

Exon	Start	End
ENSE00002700454	88082519	88082599

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 74.79.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	74.79	gold quality
gastrocnemius	UBERON:0001388	73.16	gold quality
heart	UBERON:0000948	71.93	gold quality
colon	UBERON:0001155	71.85	gold quality
right atrium auricular region	UBERON:0006631	69.72	gold quality
heart left ventricle	UBERON:0002084	69.62	gold quality
body of stomach	UBERON:0001161	65.94	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.46	gold quality
tibial nerve	UBERON:0001323	64.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.80	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.16	gold quality
esophagus mucosa	UBERON:0002469	57.15	gold quality
right testis	UBERON:0004534	44.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.