MIR4781

Summary

MIR4781 (microRNA 4781, HGNC:41769) is a microRNA gene on chromosome 1p32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616315 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41769
Approved symbol	MIR4781
Name	microRNA 4781
Location	1p32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4781
Ensembl gene	ENSG00000283749
Ensembl biotype	miRNA
Entrez	100616315
RNAcentral	URS000075CD27 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585250

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585250 — 1 exons

Exon	Start	End
ENSE00002727597	54054079	54054154

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 82.97.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.97	gold quality
muscle of leg	UBERON:0001383	77.27	gold quality
stomach	UBERON:0000945	71.64	gold quality
gastrocnemius	UBERON:0001388	71.50	gold quality
omental fat pad	UBERON:0010414	67.49	gold quality
right lobe of liver	UBERON:0001114	66.82	gold quality
body of stomach	UBERON:0001161	65.84	gold quality
colon	UBERON:0001155	63.57	gold quality
transverse colon	UBERON:0001157	60.37	gold quality
lung	UBERON:0002048	59.86	gold quality
caudate nucleus	UBERON:0001873	58.85	gold quality
left lobe of thyroid gland	UBERON:0001120	58.79	gold quality
right frontal lobe	UBERON:0002810	57.78	gold quality
thyroid gland	UBERON:0002046	56.97	gold quality
hypothalamus	UBERON:0001898	56.50	gold quality
spleen	UBERON:0002106	55.45	gold quality
right testis	UBERON:0004534	52.92	gold quality
testis	UBERON:0000473	52.74	gold quality
left testis	UBERON:0004533	51.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.