MIR4782

Summary

MIR4782 (microRNA 4782, HGNC:41635) is a microRNA gene on chromosome 2q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616208 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41635
Approved symbol	MIR4782
Name	microRNA 4782
Location	2q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4782
Ensembl gene	ENSG00000265429
Ensembl biotype	miRNA
Entrez	100616208
RNAcentral	URS000075D27E — miRNA, 79 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577987

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577987 — 1 exons

Exon	Start	End
ENSE00002719830	113721290	113721368

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 93.88.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.88	gold quality
calcaneal tendon	UBERON:0003701	85.26	gold quality
duodenum	UBERON:0002114	83.20	gold quality
adrenal tissue	UBERON:0018303	82.48	gold quality
placenta	UBERON:0001987	79.89	gold quality
lymph node	UBERON:0000029	79.67	gold quality
endometrium	UBERON:0001295	79.13	gold quality
blood	UBERON:0000178	77.51	gold quality
monocyte	CL:0000576	75.48	gold quality
muscle of leg	UBERON:0001383	75.06	gold quality
bone marrow	UBERON:0002371	75.06	gold quality
islet of Langerhans	UBERON:0000006	73.82	gold quality
right adrenal gland cortex	UBERON:0035827	73.73	gold quality
fundus of stomach	UBERON:0001160	72.87	gold quality
right adrenal gland	UBERON:0001233	72.70	gold quality
liver	UBERON:0002107	72.42	gold quality
gastrocnemius	UBERON:0001388	72.17	gold quality
kidney	UBERON:0002113	71.17	gold quality
descending thoracic aorta	UBERON:0002345	71.15	gold quality
pancreas	UBERON:0001264	70.70	gold quality
adult mammalian kidney	UBERON:0000082	70.28	gold quality
left adrenal gland	UBERON:0001234	70.21	gold quality
body of pancreas	UBERON:0001150	70.05	gold quality
stomach	UBERON:0000945	69.90	gold quality
tonsil	UBERON:0002372	69.63	gold quality
body of stomach	UBERON:0001161	69.53	gold quality
ascending aorta	UBERON:0001496	69.45	gold quality
thoracic aorta	UBERON:0001515	69.45	gold quality
left adrenal gland cortex	UBERON:0035825	69.45	gold quality
corpus callosum	UBERON:0002336	69.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MiR-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 and XIAP. (PMID:24556800)
• Study found that miR-4782-3p had low expression in hepatocellular carcinoma (HCC) tissues which correlated with shorter survival of HCC patients. Its low expression promoted HCC cells growth and inhibited cell apoptosis. Also, results confirmed that USP14 was targeted by miR-4782-3p in HCC cells. (PMID:26782643)
• The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus. (PMID:38588560)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.