MIR4783

Summary

MIR4783 (microRNA 4783, HGNC:41874) is a microRNA gene on chromosome 2q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616187 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41874
Approved symbol	MIR4783
Name	microRNA 4783
Location	2q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4783
Ensembl gene	ENSG00000264075
Ensembl biotype	miRNA
Entrez	100616187
RNAcentral	URS000075EF9E — ncRNA, 82 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580343

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580343 — 1 exons

Exon	Start	End
ENSE00002716045	127423537	127423618

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 91.54.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	91.54	gold quality
liver	UBERON:0002107	89.50	gold quality
monocyte	CL:0000576	78.78	gold quality
blood	UBERON:0000178	73.66	gold quality
adult mammalian kidney	UBERON:0000082	73.36	gold quality
gastrocnemius	UBERON:0001388	71.79	gold quality
right atrium auricular region	UBERON:0006631	71.65	gold quality
stomach	UBERON:0000945	71.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.22	gold quality
body of stomach	UBERON:0001161	70.94	gold quality
heart left ventricle	UBERON:0002084	70.12	gold quality
fundus of stomach	UBERON:0001160	70.03	gold quality
left adrenal gland cortex	UBERON:0035825	69.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.57	gold quality
body of pancreas	UBERON:0001150	67.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.56	gold quality
multicellular organism	UBERON:0000468	67.38	gold quality
metanephros cortex	UBERON:0010533	67.23	gold quality
endometrium	UBERON:0001295	67.16	gold quality
transverse colon	UBERON:0001157	67.02	gold quality
colon	UBERON:0001155	66.89	gold quality
intestine	UBERON:0000160	66.22	gold quality
right lobe of thyroid gland	UBERON:0001119	66.22	gold quality
esophagus mucosa	UBERON:0002469	66.16	gold quality
vagina	UBERON:0000996	65.85	gold quality
ascending aorta	UBERON:0001496	65.78	gold quality
thoracic aorta	UBERON:0001515	65.33	gold quality
tibial artery	UBERON:0007610	65.02	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.70	gold quality
minor salivary gland	UBERON:0001830	64.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.