MIR4784

Summary

MIR4784 (microRNA 4784, HGNC:41580) is a microRNA gene on chromosome 2q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616378 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41580
Approved symbol	MIR4784
Name	microRNA 4784
Location	2q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4784
Ensembl gene	ENSG00000284149
Ensembl biotype	miRNA
Entrez	100616378
RNAcentral	URS000075A4F6 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579560

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579560 — 1 exons

Exon	Start	End
ENSE00002685489	131491160	131491236

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 74.91.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	74.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.82	gold quality
gastrocnemius	UBERON:0001388	70.41	gold quality
Ammon’s horn	UBERON:0001954	69.49	gold quality
prefrontal cortex	UBERON:0000451	68.32	gold quality
liver	UBERON:0002107	68.15	silver quality
endometrium	UBERON:0001295	68.14	gold quality
blood	UBERON:0000178	67.09	gold quality
right lobe of thyroid gland	UBERON:0001119	65.55	gold quality
tibial artery	UBERON:0007610	65.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.16	gold quality
left coronary artery	UBERON:0001626	64.45	gold quality
body of pancreas	UBERON:0001150	64.17	gold quality
stomach	UBERON:0000945	64.13	gold quality
right adrenal gland	UBERON:0001233	63.88	gold quality
heart left ventricle	UBERON:0002084	63.55	gold quality
substantia nigra	UBERON:0002038	63.50	gold quality
lymph node	UBERON:0000029	62.60	gold quality
omental fat pad	UBERON:0010414	62.28	gold quality
heart	UBERON:0000948	61.87	gold quality
body of stomach	UBERON:0001161	61.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.03	gold quality
left adrenal gland cortex	UBERON:0035825	60.92	gold quality
caudate nucleus	UBERON:0001873	60.47	gold quality
ascending aorta	UBERON:0001496	60.23	gold quality
myometrium	UBERON:0001296	59.70	gold quality
left adrenal gland	UBERON:0001234	59.18	gold quality
hypothalamus	UBERON:0001898	58.96	gold quality
body of uterus	UBERON:0009853	58.68	gold quality
esophagus mucosa	UBERON:0002469	58.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• we unveiled that LINC01133 may function as a ceRNA for miR-4784 to advance AHDC1 expression, intensifying CC cell malignant phenotypes and EMT process, which may demonstrate the implied value of LINC01133 as a therapeutic target for CC patients. (PMID:31390932)
• ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis. (PMID:33099720)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.