MIR4785

Summary

MIR4785 (microRNA 4785, HGNC:41889) is a microRNA gene on chromosome 2q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616364 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41889
Approved symbol	MIR4785
Name	microRNA 4785
Location	2q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4785
Ensembl gene	ENSG00000283734
Ensembl biotype	miRNA
Entrez	100616364
RNAcentral	URS00007599B5 — ncRNA, 73 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585005

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585005 — 1 exons

Exon	Start	End
ENSE00002730005	160407810	160407882

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 80.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.9633 / max 89.2489, expressed in 1668 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31488	7.9633	1668

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	80.05	gold quality
adrenal tissue	UBERON:0018303	75.46	gold quality
monocyte	CL:0000576	74.66	gold quality
blood	UBERON:0000178	73.83	gold quality
fundus of stomach	UBERON:0001160	71.75	gold quality
gastrocnemius	UBERON:0001388	69.92	gold quality
urinary bladder	UBERON:0001255	69.22	gold quality
right lobe of thyroid gland	UBERON:0001119	69.18	gold quality
liver	UBERON:0002107	67.16	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.16	gold quality
right adrenal gland	UBERON:0001233	63.87	gold quality
body of stomach	UBERON:0001161	63.29	gold quality
lymph node	UBERON:0000029	62.71	gold quality
ascending aorta	UBERON:0001496	62.51	gold quality
Ammon’s horn	UBERON:0001954	62.28	gold quality
vagina	UBERON:0000996	61.88	gold quality
anterior cingulate cortex	UBERON:0009835	61.66	gold quality
substantia nigra	UBERON:0002038	61.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.91	gold quality
transverse colon	UBERON:0001157	60.53	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.37	gold quality
right adrenal gland cortex	UBERON:0035827	60.28	gold quality
left adrenal gland	UBERON:0001234	60.13	gold quality
apex of heart	UBERON:0002098	59.85	gold quality
tibial artery	UBERON:0007610	59.83	gold quality
heart left ventricle	UBERON:0002084	59.73	gold quality
omental fat pad	UBERON:0010414	59.63	gold quality
right frontal lobe	UBERON:0002810	59.60	gold quality
caudate nucleus	UBERON:0001873	59.28	gold quality
frontal cortex	UBERON:0001870	59.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.