MIR4786

Summary

MIR4786 (microRNA 4786, HGNC:41751) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616417 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41751
Approved symbol	MIR4786
Name	microRNA 4786
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4786
Ensembl gene	ENSG00000264279
Ensembl biotype	miRNA
Entrez	100616417
RNAcentral	URS000075B733 — ncRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583954

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583954 — 1 exons

Exon	Start	End
ENSE00002699238	239943015	239943094

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 83.85.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	83.85	gold quality
vermiform appendix	UBERON:0001154	83.54	gold quality
fundus of stomach	UBERON:0001160	83.39	gold quality
skeletal muscle tissue	UBERON:0001134	83.11	gold quality
duodenum	UBERON:0002114	82.45	gold quality
apex of heart	UBERON:0002098	81.67	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.00	gold quality
heart left ventricle	UBERON:0002084	80.49	gold quality
smooth muscle tissue	UBERON:0001135	79.90	gold quality
heart	UBERON:0000948	79.31	gold quality
myometrium	UBERON:0001296	79.27	gold quality
endometrium	UBERON:0001295	78.85	gold quality
popliteal artery	UBERON:0002250	78.74	gold quality
tibial artery	UBERON:0007610	78.71	gold quality
muscle of leg	UBERON:0001383	78.65	gold quality
right atrium auricular region	UBERON:0006631	78.60	gold quality
granulocyte	CL:0000094	78.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	78.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.36	gold quality
lower esophagus	UBERON:0013473	78.35	gold quality
colon	UBERON:0001155	78.34	gold quality
gastrocnemius	UBERON:0001388	77.76	gold quality
urinary bladder	UBERON:0001255	77.75	gold quality
body of uterus	UBERON:0009853	77.56	gold quality
intestine	UBERON:0000160	77.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.13	gold quality
descending thoracic aorta	UBERON:0002345	76.88	gold quality
rectum	UBERON:0001052	76.81	gold quality
cerebellar hemisphere	UBERON:0002245	76.10	gold quality
transverse colon	UBERON:0001157	76.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• high expression of hsa-miR-146b was independent poor prognostic factor and high expression of hsa-miR-181c and hsa-miR-4786 appeared to be favorable factors in younger cytogenetically normal acute myeloid leukemia patients (PMID:28473658)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.