MIR4787

Summary

MIR4787 (microRNA 4787, HGNC:41653) is a microRNA gene on chromosome 3p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616138 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41653
Approved symbol	MIR4787
Name	microRNA 4787
Location	3p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4787
Ensembl gene	ENSG00000272543
Ensembl biotype	miRNA
Entrez	100616138
RNAcentral	URS000075A45B — ncRNA, 84 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000607364

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607364 — 1 exons

Exon	Start	End
ENSE00003699821	50675080	50675163

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 66.57.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	66.57	gold quality
vagina	UBERON:0000996	62.96	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.52	gold quality
skin of abdomen	UBERON:0001416	56.08	gold quality
left uterine tube	UBERON:0001303	52.30	gold quality
myometrium	UBERON:0001296	48.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-4787-5p Regulates Vascular Smooth Muscle Cell Apoptosis by Targeting PKD1 and Inhibiting the PI3K/Akt/FKHR Pathway. (PMID:33958547)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.