MIR4789

Summary

MIR4789 (microRNA 4789, HGNC:41719) is a microRNA gene on chromosome 3q26.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616395 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41719
Approved symbol	MIR4789
Name	microRNA 4789
Location	3q26.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4789
Ensembl gene	ENSG00000264974
Ensembl biotype	miRNA
Entrez	100616395
RNAcentral	URS000075E1DB — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577469

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577469 — 1 exons

Exon	Start	End
ENSE00002730101	175369540	175369621

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 85.22.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	85.22	gold quality
kidney	UBERON:0002113	81.28	gold quality
calcaneal tendon	UBERON:0003701	78.36	gold quality
liver	UBERON:0002107	78.16	gold quality
stomach	UBERON:0000945	77.49	gold quality
heart	UBERON:0000948	75.17	gold quality
intestine	UBERON:0000160	72.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.98	gold quality
lung	UBERON:0002048	68.29	gold quality
heart left ventricle	UBERON:0002084	66.59	gold quality
caudate nucleus	UBERON:0001873	66.27	gold quality
popliteal artery	UBERON:0002250	65.87	gold quality
skin of leg	UBERON:0001511	65.77	gold quality
endometrium	UBERON:0001295	65.53	gold quality
body of stomach	UBERON:0001161	65.31	gold quality
ascending aorta	UBERON:0001496	64.91	gold quality
colon	UBERON:0001155	64.49	gold quality
left coronary artery	UBERON:0001626	63.98	gold quality
skin of abdomen	UBERON:0001416	63.74	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.45	gold quality
cerebellar hemisphere	UBERON:0002245	63.26	gold quality
body of pancreas	UBERON:0001150	63.16	gold quality
putamen	UBERON:0001874	62.97	gold quality
esophagus mucosa	UBERON:0002469	62.87	gold quality
transverse colon	UBERON:0001157	62.80	gold quality
left ovary	UBERON:0002119	62.76	gold quality
left lobe of thyroid gland	UBERON:0001120	62.12	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.92	gold quality
tibial nerve	UBERON:0001323	61.46	gold quality
thoracic mammary gland	UBERON:0005200	60.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.