MIR4791

Summary

MIR4791 (microRNA 4791, HGNC:41704) is a microRNA gene on chromosome 3p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616291 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41704
Approved symbol	MIR4791
Name	microRNA 4791
Location	3p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4791
Ensembl gene	ENSG00000271898
Ensembl biotype	miRNA
Entrez	100616291
RNAcentral	URS000075EF37 — miRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000607666

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607666 — 1 exons

Exon	Start	End
ENSE00003697993	19314848	19314931

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 75.70.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	75.70	gold quality
intestine	UBERON:0000160	75.21	gold quality
kidney	UBERON:0002113	73.79	gold quality
corpus callosum	UBERON:0002336	69.29	gold quality
stomach	UBERON:0000945	66.37	gold quality
right frontal lobe	UBERON:0002810	66.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.27	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.32	gold quality
body of stomach	UBERON:0001161	63.73	gold quality
minor salivary gland	UBERON:0001830	63.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.38	gold quality
omental fat pad	UBERON:0010414	63.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.11	gold quality
pituitary gland	UBERON:0000007	62.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.12	gold quality
tibial nerve	UBERON:0001323	60.60	gold quality
skin of leg	UBERON:0001511	57.30	gold quality
skin of abdomen	UBERON:0001416	57.11	gold quality
left testis	UBERON:0004533	51.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.