MIR4793

Summary

MIR4793 (microRNA 4793, HGNC:41538) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616112 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41538
Approved symbol	MIR4793
Name	microRNA 4793
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4793
Ensembl gene	ENSG00000284575
Ensembl biotype	miRNA
Entrez	100616112
RNAcentral	URS000075E948 — ncRNA, 87 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577502

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577502 — 1 exons

Exon	Start	End
ENSE00002733035	48644194	48644280

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 83.47.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	83.47	gold quality
cerebellar hemisphere	UBERON:0002245	81.58	gold quality
pituitary gland	UBERON:0000007	81.56	gold quality
vermiform appendix	UBERON:0001154	80.47	gold quality
bone marrow	UBERON:0002371	80.20	gold quality
adrenal tissue	UBERON:0018303	79.72	gold quality
adenohypophysis	UBERON:0002196	78.82	gold quality
islet of Langerhans	UBERON:0000006	75.32	gold quality
brain	UBERON:0000955	74.07	gold quality
granulocyte	CL:0000094	73.79	gold quality
right frontal lobe	UBERON:0002810	72.88	gold quality
gastrocnemius	UBERON:0001388	72.85	gold quality
gall bladder	UBERON:0002110	72.75	gold quality
lymph node	UBERON:0000029	72.61	gold quality
blood	UBERON:0000178	71.48	gold quality
cerebral cortex	UBERON:0000956	70.71	gold quality
left uterine tube	UBERON:0001303	70.63	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.63	gold quality
right atrium auricular region	UBERON:0006631	70.44	gold quality
right lobe of liver	UBERON:0001114	70.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.83	gold quality
anterior cingulate cortex	UBERON:0009835	69.46	gold quality
stomach	UBERON:0000945	69.37	gold quality
fundus of stomach	UBERON:0001160	69.14	gold quality
adrenal gland	UBERON:0002369	69.02	gold quality
body of stomach	UBERON:0001161	68.86	gold quality
nucleus accumbens	UBERON:0001882	68.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.68	gold quality
body of pancreas	UBERON:0001150	68.64	gold quality
heart left ventricle	UBERON:0002084	68.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer. (PMID:34354043)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.