MIR4794

Summary

MIR4794 (microRNA 4794, HGNC:41829) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616338 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41829
Approved symbol	MIR4794
Name	microRNA 4794
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4794
Ensembl gene	ENSG00000264470
Ensembl biotype	miRNA
Entrez	100616338
RNAcentral	URS000075E9B5 — ncRNA, 77 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582305

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582305 — 1 exons

Exon	Start	End
ENSE00002703893	64579847	64579923

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 78.74.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	78.74	gold quality
endometrium	UBERON:0001295	77.50	gold quality
blood	UBERON:0000178	76.86	gold quality
kidney	UBERON:0002113	74.96	gold quality
lung	UBERON:0002048	74.63	gold quality
stomach	UBERON:0000945	74.29	gold quality
heart	UBERON:0000948	74.16	gold quality
calcaneal tendon	UBERON:0003701	73.12	gold quality
caudate nucleus	UBERON:0001873	72.38	gold quality
intestine	UBERON:0000160	72.10	gold quality
tibial artery	UBERON:0007610	70.64	gold quality
right atrium auricular region	UBERON:0006631	68.85	gold quality
putamen	UBERON:0001874	68.45	gold quality
adult mammalian kidney	UBERON:0000082	67.99	gold quality
gastrocnemius	UBERON:0001388	67.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.53	gold quality
body of stomach	UBERON:0001161	66.16	gold quality
ascending aorta	UBERON:0001496	66.14	gold quality
left coronary artery	UBERON:0001626	66.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.88	gold quality
thoracic mammary gland	UBERON:0005200	65.74	gold quality
colon	UBERON:0001155	65.21	gold quality
esophagus mucosa	UBERON:0002469	65.21	gold quality
skin of leg	UBERON:0001511	65.01	gold quality
hypothalamus	UBERON:0001898	64.58	gold quality
omental fat pad	UBERON:0010414	64.58	gold quality
left adrenal gland	UBERON:0001234	63.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.70	gold quality
right ovary	UBERON:0002118	63.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.