MIR4796

Summary

MIR4796 (microRNA 4796, HGNC:41779) is a microRNA gene on chromosome 3q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616166 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41779
Approved symbol	MIR4796
Name	microRNA 4796
Location	3q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4796
Ensembl gene	ENSG00000264623
Ensembl biotype	miRNA
Entrez	100616166
RNAcentral	URS000075A67E — miRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580742

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580742 — 1 exons

Exon	Start	End
ENSE00002723642	114743445	114743525

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 86.24.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	86.24	gold quality
kidney	UBERON:0002113	84.02	gold quality
corpus callosum	UBERON:0002336	83.89	gold quality
liver	UBERON:0002107	83.72	gold quality
adult mammalian kidney	UBERON:0000082	80.35	gold quality
blood	UBERON:0000178	80.25	gold quality
adrenal tissue	UBERON:0018303	77.98	gold quality
endometrium	UBERON:0001295	77.03	gold quality
monocyte	CL:0000576	76.07	gold quality
islet of Langerhans	UBERON:0000006	72.77	gold quality
gastrocnemius	UBERON:0001388	71.67	gold quality
stomach	UBERON:0000945	71.47	gold quality
heart	UBERON:0000948	69.43	gold quality
heart left ventricle	UBERON:0002084	68.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.92	gold quality
body of pancreas	UBERON:0001150	67.84	gold quality
transverse colon	UBERON:0001157	67.04	gold quality
ascending aorta	UBERON:0001496	66.76	gold quality
right lobe of thyroid gland	UBERON:0001119	66.41	gold quality
intestine	UBERON:0000160	65.97	gold quality
tibial artery	UBERON:0007610	65.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.11	gold quality
descending thoracic aorta	UBERON:0002345	64.96	gold quality
skin of leg	UBERON:0001511	64.71	gold quality
skin of abdomen	UBERON:0001416	64.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.64	gold quality
right lobe of liver	UBERON:0001114	64.58	gold quality
omental fat pad	UBERON:0010414	64.24	gold quality
colon	UBERON:0001155	64.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-4796 enhances the sensitivity of breast cancer cells to ionising radiation by impairing the DNA repair pathway. (PMID:37460775)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.