MIR4797

Summary

MIR4797 (microRNA 4797, HGNC:41758) is a microRNA gene on chromosome 3q29.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616216 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41758
Approved symbol	MIR4797
Name	microRNA 4797
Location	3q29
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4797
Ensembl gene	ENSG00000265850
Ensembl biotype	miRNA
Entrez	100616216
RNAcentral	URS000075B314 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577559

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577559 — 1 exons

Exon	Start	End
ENSE00002701277	197293878	197293948

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 86.60.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	86.60	gold quality
muscle of leg	UBERON:0001383	84.81	gold quality
endometrium	UBERON:0001295	79.11	gold quality
lung	UBERON:0002048	74.52	gold quality
blood	UBERON:0000178	74.10	gold quality
monocyte	CL:0000576	73.99	gold quality
thoracic mammary gland	UBERON:0005200	72.21	gold quality
islet of Langerhans	UBERON:0000006	72.09	gold quality
right atrium auricular region	UBERON:0006631	72.04	gold quality
adult mammalian kidney	UBERON:0000082	70.17	gold quality
omental fat pad	UBERON:0010414	69.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.32	gold quality
skin of abdomen	UBERON:0001416	67.46	gold quality
transverse colon	UBERON:0001157	67.22	gold quality
upper lobe of left lung	UBERON:0008952	65.39	gold quality
ascending aorta	UBERON:0001496	64.66	gold quality
left ovary	UBERON:0002119	64.28	gold quality
esophagus mucosa	UBERON:0002469	63.81	gold quality
skin of leg	UBERON:0001511	63.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.51	gold quality
left lobe of thyroid gland	UBERON:0001120	61.26	gold quality
cerebellar hemisphere	UBERON:0002245	61.11	gold quality
thyroid gland	UBERON:0002046	60.18	gold quality
pituitary gland	UBERON:0000007	59.13	gold quality
spleen	UBERON:0002106	58.77	gold quality
body of uterus	UBERON:0009853	58.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.19	gold quality
corpus callosum	UBERON:0002336	46.60	silver quality
left testis	UBERON:0004533	38.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.