MIR4798

Summary

MIR4798 (microRNA 4798, HGNC:41616) is a microRNA gene on chromosome 4p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616471 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41616
Approved symbol	MIR4798
Name	microRNA 4798
Location	4p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4798
Ensembl gene	ENSG00000264658
Ensembl biotype	miRNA
Entrez	100616471
RNAcentral	URS000075B320 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578126 — 1 exons

Exon	Start	End
ENSE00002708350	7310450	7310524

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 84.56.

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	84.56	gold quality
adrenal tissue	UBERON:0018303	78.75	gold quality
lung	UBERON:0002048	76.16	gold quality
monocyte	CL:0000576	72.93	gold quality
putamen	UBERON:0001874	72.89	gold quality
heart left ventricle	UBERON:0002084	72.59	gold quality
right lobe of liver	UBERON:0001114	72.06	gold quality
stomach	UBERON:0000945	71.65	gold quality
heart	UBERON:0000948	70.81	gold quality
prostate gland	UBERON:0002367	69.72	gold quality
corpus callosum	UBERON:0002336	69.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.54	gold quality
substantia nigra	UBERON:0002038	65.22	gold quality
omental fat pad	UBERON:0010414	65.07	gold quality
right lobe of thyroid gland	UBERON:0001119	64.95	gold quality
body of uterus	UBERON:0009853	64.57	gold quality
skin of leg	UBERON:0001511	64.10	gold quality
tibial artery	UBERON:0007610	63.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.25	gold quality
skin of abdomen	UBERON:0001416	62.90	gold quality
esophagus mucosa	UBERON:0002469	62.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.29	gold quality
right atrium auricular region	UBERON:0006631	62.28	gold quality
tibial nerve	UBERON:0001323	61.78	gold quality
pituitary gland	UBERON:0000007	61.58	gold quality
Ammon’s horn	UBERON:0001954	61.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.