MIR4799

Summary

MIR4799 (microRNA 4799, HGNC:41584) is a microRNA gene on chromosome 4q31.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616246 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41584
Approved symbol	MIR4799
Name	microRNA 4799
Location	4q31.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4799
Ensembl gene	ENSG00000264274
Ensembl biotype	miRNA
Entrez	100616246
RNAcentral	URS000075A1E8 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578951

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578951 — 1 exons

Exon	Start	End
ENSE00002706236	147782595	147782668

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 86.38.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.38	gold quality
calcaneal tendon	UBERON:0003701	78.17	gold quality
endometrium	UBERON:0001295	76.29	gold quality
blood	UBERON:0000178	74.99	gold quality
gastrocnemius	UBERON:0001388	71.76	gold quality
heart left ventricle	UBERON:0002084	71.20	gold quality
left coronary artery	UBERON:0001626	70.39	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.84	gold quality
ascending aorta	UBERON:0001496	69.57	gold quality
adult mammalian kidney	UBERON:0000082	69.48	gold quality
heart	UBERON:0000948	69.22	gold quality
tibial artery	UBERON:0007610	68.55	gold quality
popliteal artery	UBERON:0002250	68.43	gold quality
ectocervix	UBERON:0012249	67.25	gold quality
minor salivary gland	UBERON:0001830	66.99	gold quality
kidney	UBERON:0002113	66.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.41	gold quality
anterior cingulate cortex	UBERON:0009835	66.11	gold quality
Ammon’s horn	UBERON:0001954	66.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.68	gold quality
body of stomach	UBERON:0001161	65.38	gold quality
esophagus mucosa	UBERON:0002469	64.77	gold quality
right atrium auricular region	UBERON:0006631	64.34	gold quality
tibial nerve	UBERON:0001323	64.28	gold quality
left ovary	UBERON:0002119	64.26	gold quality
intestine	UBERON:0000160	64.05	gold quality
stomach	UBERON:0000945	63.87	gold quality
skin of leg	UBERON:0001511	63.85	gold quality
omental fat pad	UBERON:0010414	63.82	gold quality
skin of abdomen	UBERON:0001416	63.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.