MIR4801

Summary

MIR4801 (microRNA 4801, HGNC:41840) is a microRNA gene on chromosome 4p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616435 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41840
Approved symbol	MIR4801
Name	microRNA 4801
Location	4p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4801
Ensembl gene	ENSG00000264319
Ensembl biotype	miRNA
Entrez	100616435
RNAcentral	URS000075CA01 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582704

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582704 — 1 exons

Exon	Start	End
ENSE00002684282	37241910	37241991

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 92.48.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	92.48	gold quality
endometrium	UBERON:0001295	78.10	gold quality
intestine	UBERON:0000160	71.92	gold quality
left coronary artery	UBERON:0001626	70.93	gold quality
prefrontal cortex	UBERON:0000451	70.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.67	gold quality
monocyte	CL:0000576	69.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.61	gold quality
substantia nigra	UBERON:0002038	68.44	gold quality
omental fat pad	UBERON:0010414	67.88	gold quality
adipose tissue	UBERON:0001013	67.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.19	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.48	gold quality
cerebral cortex	UBERON:0000956	66.11	gold quality
fundus of stomach	UBERON:0001160	65.40	gold quality
thoracic mammary gland	UBERON:0005200	65.29	gold quality
anterior cingulate cortex	UBERON:0009835	65.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.00	gold quality
Ammon’s horn	UBERON:0001954	64.91	gold quality
frontal cortex	UBERON:0001870	64.84	gold quality
ascending aorta	UBERON:0001496	64.53	gold quality
amygdala	UBERON:0001876	64.22	gold quality
right frontal lobe	UBERON:0002810	64.02	gold quality
hypothalamus	UBERON:0001898	63.67	gold quality
caudate nucleus	UBERON:0001873	63.64	gold quality
skin of abdomen	UBERON:0001416	63.35	gold quality
cerebellar hemisphere	UBERON:0002245	62.97	gold quality
prostate gland	UBERON:0002367	62.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.