MIR4803

Summary

MIR4803 (microRNA 4803, HGNC:41568) is a microRNA gene on chromosome 5q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616377 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41568
Approved symbol	MIR4803
Name	microRNA 4803
Location	5q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4803
Ensembl gene	ENSG00000264099
Ensembl biotype	miRNA
Entrez	100616377
RNAcentral	URS000075DD15 — miRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583015

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583015 — 1 exons

Exon	Start	End
ENSE00002703662	72169467	72169540

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 83.22.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	83.22	gold quality
stomach	UBERON:0000945	80.19	gold quality
heart	UBERON:0000948	77.93	gold quality
blood	UBERON:0000178	77.24	gold quality
lung	UBERON:0002048	77.21	gold quality
endometrium	UBERON:0001295	76.81	gold quality
kidney	UBERON:0002113	76.40	gold quality
calcaneal tendon	UBERON:0003701	75.75	gold quality
gastrocnemius	UBERON:0001388	74.07	gold quality
intestine	UBERON:0000160	71.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.89	gold quality
left adrenal gland cortex	UBERON:0035825	69.37	gold quality
liver	UBERON:0002107	67.89	gold quality
body of pancreas	UBERON:0001150	67.68	gold quality
left adrenal gland	UBERON:0001234	67.30	gold quality
heart left ventricle	UBERON:0002084	66.88	gold quality
right atrium auricular region	UBERON:0006631	66.64	gold quality
colon	UBERON:0001155	66.55	gold quality
popliteal artery	UBERON:0002250	65.94	gold quality
substantia nigra	UBERON:0002038	65.93	gold quality
ascending aorta	UBERON:0001496	65.86	gold quality
tibial artery	UBERON:0007610	65.83	gold quality
transverse colon	UBERON:0001157	65.59	gold quality
thoracic aorta	UBERON:0001515	65.54	gold quality
body of uterus	UBERON:0009853	65.54	gold quality
body of stomach	UBERON:0001161	65.17	gold quality
spleen	UBERON:0002106	65.16	gold quality
left coronary artery	UBERON:0001626	64.91	gold quality
right frontal lobe	UBERON:0002810	64.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.