MIR4804

Summary

MIR4804 (microRNA 4804, HGNC:41720) is a microRNA gene on chromosome 5q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616152 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41720
Approved symbol	MIR4804
Name	microRNA 4804
Location	5q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4804
Ensembl gene	ENSG00000263593
Ensembl biotype	miRNA
Entrez	100616152
RNAcentral	URS0000759EA5 — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581683

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581683 — 1 exons

Exon	Start	End
ENSE00002714012	72878591	72878663

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 90.49.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	90.49	gold quality
adrenal tissue	UBERON:0018303	79.42	gold quality
bone marrow	UBERON:0002371	78.84	gold quality
blood	UBERON:0000178	78.23	gold quality
endometrium	UBERON:0001295	75.27	gold quality
calcaneal tendon	UBERON:0003701	74.99	gold quality
monocyte	CL:0000576	74.67	gold quality
liver	UBERON:0002107	73.62	gold quality
gastrocnemius	UBERON:0001388	73.53	gold quality
corpus callosum	UBERON:0002336	72.11	gold quality
heart	UBERON:0000948	70.72	gold quality
stomach	UBERON:0000945	70.63	gold quality
left coronary artery	UBERON:0001626	70.24	gold quality
body of stomach	UBERON:0001161	69.49	gold quality
right atrium auricular region	UBERON:0006631	68.69	gold quality
amygdala	UBERON:0001876	68.62	gold quality
left adrenal gland cortex	UBERON:0035825	68.33	gold quality
tibial artery	UBERON:0007610	68.05	gold quality
popliteal artery	UBERON:0002250	68.01	gold quality
ascending aorta	UBERON:0001496	67.98	gold quality
urinary bladder	UBERON:0001255	67.83	gold quality
lung	UBERON:0002048	67.57	gold quality
left adrenal gland	UBERON:0001234	67.29	gold quality
ectocervix	UBERON:0012249	67.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.97	gold quality
body of pancreas	UBERON:0001150	66.80	gold quality
myometrium	UBERON:0001296	66.72	gold quality
tonsil	UBERON:0002372	66.64	gold quality
body of uterus	UBERON:0009853	66.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.