MIR484

Summary

MIR484 (microRNA 484, HGNC:32341) is a microRNA gene on chromosome 16p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 619553 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32341
Approved symbol	MIR484
Name	microRNA 484
Location	16p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-484
Ensembl gene	ENSG00000283736
Ensembl biotype	miRNA
Entrez	619553
RNAcentral	URS00005651EE — miRNA, 79 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000606601

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606601 — 1 exons

Exon	Start	End
ENSE00003700953	15643294	15643372

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 83.02.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.09	gold quality
left testis	UBERON:0004533	25.51	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways (PMID:23697367)
• Significant serum levels of MIR484 are differentially expressed in early breast cancer patients compared to those of healthy volunteers. (PMID:24641801)
• miR-484-modulated cytidine deaminase has a dual impact in promoting chemoresistance and suppressing cell proliferation in breast cancer (PMID:25643696)
• detection of serum miR-484-5p and miR-484 may be useful for early diagnosis of colorectal cancer (PMID:25807655)
• Low MIR484 expression is associated with chronic lymphocytic leukemia. (PMID:25936528)
• miR-155 and miR-484 are potentially connected with sunitinib resistance and failure of the therapy. miR-155 is a known oncogene with direct influence on neovascularization. Biological role of miR-484 has to be clarified. (PMID:26064968)
• MiR-484 accelerated the non-small-cell lung cancer cell progression associated with the inhibition of apoptosis. (PMID:28982084)
• The study suggested that ZFAS1 could act as an oncogene in colorectal cancer tumorigenesis, and discovered the functional regulatory pathway of ZFAS1 sponging miR-484. (PMID:29179614)
• study suggests that miR-484 and MAP2 can be utilized as predictors for the clinical diagnosis and prognosis of glioma (PMID:29480405)
• 16p13.11 microduplication in 45 new patients: refined clinical significance and genotype-phenotype correlations. (PMID:30287593)
• circADAMTS13 can serve as a tumor suppressor during hepatocellular carcinoma progression via the functional pathway of sponging miR-484. (PMID:30537115)
• we show that these effects are probably caused by direct miRNA/mRNA interaction, which are reversible by Pax-5 recombinant expression. Interestingly, miRNAs 484 and 210, which are both overexpressed in clinical tumor samples, are also modulated during epithelial-mesenchymal transitioning and hypoxia that correlate inversely to Pax-5 expression. (PMID:30605519)
• The miR-484/TUSC5 is potential diagnostic biomarkers and therapy targets for Hepatocellular carcinoma (HCC). (PMID:31157375)
• Nucleolin (NCL) is a major regulator of miR processing in response to OS and essential for the maturation of miR-93 and miR-484 that target mRNAs encoding KLF2 and eNOS. AMPK phosphorylation of NCL sequesters it in the nucleus, thereby inhibiting miR-93 and miR-484 processing and their subsequent targeting of KLF2 and eNOS mRNA. Elevated levels of miR-93 and miR-484 were found in sera of coronary artery disease patients. (PMID:31182601)
• lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP. (PMID:31831555)
• Low serum exosomal miR-484 expression predicts unfavorable prognosis in ovarian cancer. (PMID:32065786)
• Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer. (PMID:32192507)
• Long noncoding RNA PVT1 promotes metastasis via miR-484 sponging in osteosarcoma cells. (PMID:32196583)
• miR-484 is associated with disease recurrence and promotes migration in prostate cancer. (PMID:32338277)
• The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer. (PMID:32354224)
• miR-484 suppresses endocrine therapy-resistant cells by inhibiting KLF4-induced cancer stem cells in estrogen receptor-positive cancers. (PMID:32865695)
• MiR-484 suppressed proliferation, migration, invasion and induced apoptosis of gastric cancer via targeting CCL-18. (PMID:32985776)
• Pathway Analysis of Selected Circulating miRNAs in Plasma of Breast Cancer Patients: A Preliminary Study. (PMID:33023154)
• miR-484: A Possible Indicator of Drug-Induced Pulmonary Fibrosis. (PMID:33259780)
• Targeted delivery of exosomal miR-484 reprograms tumor vasculature for chemotherapy sensitization. (PMID:35051533)
• Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis. (PMID:35173533)
• Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression. (PMID:36657426)
• MiR-484 promotes the malignant progression of glioma by inhibiting CDKN2A expression. (PMID:37818686)
• Identification of exosomal miR-484 role in reprogramming mitochondrial metabolism in pancreatic cancer through Wnt/MAPK axis control. (PMID:37944835)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir484	ENSMUSG00000070074

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.