MIR485

Summary

MIR485 (microRNA 485, HGNC:32067) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574436 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32067
Approved symbol	MIR485
Name	microRNA 485
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-485
Ensembl gene	ENSG00000208027
Ensembl biotype	miRNA
OMIM	615385
Entrez	574436
RNAcentral	URS000075D081 — miRNA, 73 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385292 — 1 exons

Exon	Start	End
ENSE00001500298	101055419	101055491

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 88.77.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.77	gold quality
placenta	UBERON:0001987	83.46	gold quality
intestine	UBERON:0000160	81.34	gold quality
colon	UBERON:0001155	81.33	gold quality
stomach	UBERON:0000945	80.91	gold quality
blood	UBERON:0000178	77.61	gold quality
lung	UBERON:0002048	76.66	gold quality
kidney	UBERON:0002113	75.21	gold quality
heart	UBERON:0000948	74.84	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.18	gold quality
body of stomach	UBERON:0001161	72.37	gold quality
right atrium auricular region	UBERON:0006631	72.05	gold quality
left adrenal gland cortex	UBERON:0035825	71.21	gold quality
monocyte	CL:0000576	71.20	gold quality
adult mammalian kidney	UBERON:0000082	71.16	gold quality
islet of Langerhans	UBERON:0000006	70.37	gold quality
left ovary	UBERON:0002119	69.27	gold quality
adipose tissue	UBERON:0001013	68.78	gold quality
transverse colon	UBERON:0001157	67.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.11	gold quality
right adrenal gland	UBERON:0001233	66.99	gold quality
left adrenal gland	UBERON:0001234	66.73	gold quality
omental fat pad	UBERON:0010414	66.26	gold quality
substantia nigra	UBERON:0002038	66.22	gold quality
right frontal lobe	UBERON:0002810	65.92	gold quality
upper lobe of left lung	UBERON:0008952	65.01	gold quality
tibial artery	UBERON:0007610	64.98	gold quality
ascending aorta	UBERON:0001496	64.87	gold quality
cerebellar hemisphere	UBERON:0002245	64.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumors. (PMID:21083603)
• MicroRNA-485-3p mediates DNA topoisomerase IIalpha down-regulation by altered regulation of nuclear factor-YB. (PMID:21252292)
• MiR-485-3p-mediated repression of FPN may also offer a novel potential therapeutic mechanism for circumventing hepcidin-resistant mechanisms responsible for some iron overload diseases. (PMID:23593016)
• Decreased miR-485 expression was associated with breast carcinoma. (PMID:23886178)
• Mir-485-3p, mapped to the 14q32.31 locus, regulates proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID:24166498)
• luciferase reporter constructs containing the 3’UTR of HIF3alpha were used to demonstrate regulation of HIF3alpha by miR-210-3p and miR-485-5p (PMID:24927770)
• A single nucleotide polymorphism in the 3’ untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene modifies mir-485-5p binding in breast cancer. (PMID:25003827)
• Results suggest that MiR-485-5p participate sin the regulation of senescence status and cell cycle characteristics of Multiple myeloma-bone marrow mesenchymal stromal cells. (PMID:25886144)
• miR-485-5p represses hepatocellular carcinoma invasive and metastatic capacities by targeting EMMPRIN expression. (PMID:26054676)
• Validation of significant miRNAs in independent 40 paired NSCLC tissues demonstrated that the expression level of miR-486-5p and miR-30a-5p was significantly downregulated in another 40 paired lung cancer tissues (PMID:26238736)
• miR4855p inhibits cell metastasis and EMT at least partly through the suppression of HMGA2 expression. (PMID:26239806)
• These findings highlight the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection. (PMID:26645583)
• MiR-485-5p was significantly down-regulated in 50 pairs of human hepatocellular carcinoma tissues. Stanniocalcin 2 was a direct target of miR-485-5p. (PMID:26722415)
• Overexpression of miR-485-3p and miR-485-5p suppressed mitochondrial respiration and potential for cell migration and invasion in vitro, and also inhibited spontaneous metastasis of breast cancer cells in vivo. (PMID:27010860)
• Ectopic Flot2 could significantly reverse miR-485-mediated inhibition of metastasis and EMT, demonstrating Flot2 downregulation is involved in function of miR-485 (PMID:27262438)
• LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3’UTR. (PMID:27351280)
• These data for the first time identifies miR-485-5p/TRADD axis in hydrogen sulfide protecting against TNF-alpha-induced neuronal cell apoptosis. (PMID:27562714)
• The miR-485-5p/FZD7 axis may provide novel insights into understanding the molecular pathogenesis of melanoma. (PMID:28364602)
• miR4855p reverses EMT and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma. This study suggests that PAK1 plays an essential role in the progression of OSCC and it is a potential therapeutic target for OSCC. (PMID:28535002)
• Low serum level of miR-485-3p is associated with glioblastoma. (PMID:28931080)
• These results indicate that miR485 acts as a tumour suppressor in Glioblastoma (GBM)by, at least partially, directly targeting PAK4 and regulating the AKT and ERK signalling pathways. Thus, miR485 may be a potential target for the treatment of patients with GBM. (PMID:29048626)
• NEAT1 can act as a competing endogenous lncRNA (ceRNA) to regulated STAT3 by sponging miR-485 in HCC. (PMID:29219178)
• Low miR-485-5p expression predicts poor prognosis in non-small cell lung cancer. (PMID:29510198)
• Study shows that miR4855p is downregulated in colorectal cancer (CRC). It inhibits tumor development by targeting gene expression of CD147 in CRC. (PMID:29532886)
• Overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity. Further study demonstrated that miR-485-5p directly targeted the 3’-untranslated region of survivin and overexpression of survivin overcomes the miR-485-5p induced effects on breast cancer. (PMID:29678577)
• that as a tumor suppressor, miR-485-5p may regulate colorectal cancer cells proliferation, which could regulate the O-GlcNAcylation and the stability of Bmi-1 through targeting OGT (PMID:29680296)
• overexpression of miR-31 and miR-485-p contribute to skin inflammation in DLE lesions by regulating the production of inflammatory mediators and attracting neutrophils and intermediate monocytes to the skin. (PMID:30130620)
• DSCR8 activates Wnt/beta-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis. (PMID:30154476)
• miR-485-5p/CX3CL1 axis controls metastasis and proliferation of osteosarcoma cells. (PMID:30468463)
• It has been concluded that miR-485-5p, as a tumor suppressor, inhibits the growth and metastasis in small cell lung cancer cells by targeting FLOT2. (PMID:30836864)
• MiRNA-485-5p, inhibits esophageal cancer cells proliferation and invasion by down-regulating O-linked N-acetylglucosamine transferase. (PMID:31002132)
• Overexpression of circ-10021 promotes the proliferative and migratory capacities of breast cancer cells by sponging microRNA-485-3p to upregulate the NTRK3 expression. (PMID:31127997)
• BLACAT1 is aberrantly upregulated in hepatocellular carcinoma (HCC) and its inhibition had tumor suppressing effects in human HCC, possibly through endogenously competing against has-miR-485-5p. (PMID:31174090)
• MiRNA-485-5p suppresses the proliferation of acute myeloid leukemia via targeting SALL4. (PMID:31210317)
• MIR485 is a novel regulator of UGT2B7 and UGT2B10 in liver microsomes. (PMID:31554697)
• microRNA-485-5p inhibits the progression of hepatocellular carcinoma through blocking the WBP2/Wnt signaling pathway. (PMID:31706018)
• These results provide new insights into the involvement of the miR-485-NOX5 signaling pathway in diabetic nephtopathy progression. (PMID:31727371)
• Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis. (PMID:31794744)
• Circulating miRNAs are associated with sleep duration in children/adolescents: Results of the I.Family Study. (PMID:31916337)
• MiR-485-5p as a potential biomarker and tumor suppressor in human colorectal cancer. (PMID:31984757)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.