MIR486-1

Summary

MIR486-1 (microRNA 486-1, HGNC:32342) is a microRNA gene on chromosome 8p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 619554 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32342
Approved symbol	MIR486-1
Name	microRNA 486-1
Location	8p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-486
Ensembl gene	ENSG00000274705
Ensembl biotype	miRNA
Entrez	619554
RNAcentral	URS000071BDB0 — miRNA, 68 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612171

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612171 — 1 exons

Exon	Start	End
ENSE00003723437	41660441	41660508

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 94.57.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	94.57	gold quality
apex of heart	UBERON:0002098	90.67	gold quality
bone marrow	UBERON:0002371	89.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.69	gold quality
muscle of leg	UBERON:0001383	85.31	gold quality
cerebellar hemisphere	UBERON:0002245	83.62	gold quality
gastrocnemius	UBERON:0001388	83.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.08	gold quality
heart left ventricle	UBERON:0002084	80.54	gold quality
heart	UBERON:0000948	79.69	gold quality
lymph node	UBERON:0000029	78.30	gold quality
right atrium auricular region	UBERON:0006631	78.26	gold quality
blood	UBERON:0000178	75.06	gold quality
monocyte	CL:0000576	74.31	gold quality
fundus of stomach	UBERON:0001160	74.27	gold quality
stomach	UBERON:0000945	73.99	gold quality
minor salivary gland	UBERON:0001830	73.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.37	gold quality
body of stomach	UBERON:0001161	72.96	gold quality
prefrontal cortex	UBERON:0000451	71.13	gold quality
myometrium	UBERON:0001296	71.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.84	gold quality
vagina	UBERON:0000996	70.76	gold quality
descending thoracic aorta	UBERON:0002345	70.67	gold quality
pancreas	UBERON:0001264	70.66	gold quality
left uterine tube	UBERON:0001303	70.42	gold quality
amygdala	UBERON:0001876	70.26	gold quality
right adrenal gland cortex	UBERON:0035827	70.26	gold quality
body of pancreas	UBERON:0001150	69.92	gold quality
left adrenal gland cortex	UBERON:0035825	69.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SRF

Literature-anchored findings (GeneRIF, showing 40)

• overexpression of microRNA 486 is associated with highly invasive and metastatic pancreatic ductal adenocarcinomas. (PMID:19475450)
• miR-486 may function as a novel tumor-suppressor miRNA in gastric cancer. Its antioncogenic activity may involve the direct targeting and inhibition of OLFM4. (PMID:21415212)
• MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome (PMID:21525938)
• Exposure to high glucose increases miR-486-5p expression and inhibits SIRT1 expression in human adipose tissue-derived mesenchymal stem cells. (PMID:21988232)
• these results suggest a novel essential molecular mechanism that TLS-CHOP activates PAI-1 expression by repression of miR-486 expression in myxoid liposarcoma tumorigenesis and development. (PMID:22995304)
• miR-486 plays important roles in glioma progression and that miR-486 is a critical mediator involved in prolonged NF-kappaB activation. (PMID:23247627)
• miR-486-3p might contribute to different HbF levels observed among thalassemic patients and, possibly, to the clinical severity of the disease. (PMID:23593217)
• miR-486 directly targets components of insulin growth factor (IGF) signaling including IGF1, IGF1 receptor, and phosphoinositide-3-kinase, regulatory subunit 1alpha (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer. (PMID:23980150)
• miRNA-21 was significantly higher in plasma and in EBC of the NSCLC patients and miRNA-486 was significantly lower (PMID:24102090)
• Data suggest that down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients. (PMID:25027758)
• Low expression of miR-486-5p is associated with breast cancer. (PMID:25104088)
• Pim-1 kinase could be a critical survival signaling factor in non-small-cell lung cancer, and regulated by miR-486-5p and eIF4E. (PMID:25342548)
• A novel role for miR-486-5p in regulating normal hematopoiesis and of BCR-ABL-induced miR-486-5p overexpression in modulating Chronic myeloid leukemia progenitor growth, survival, and drug sensitivity. (PMID:25515961)
• miR-486-5p cooperates with GATA1s in supporting the growth and survival, and the aberrant erythroid phenotype of the megakaryocytic leukemias of Down syndrome. (PMID:25533034)
• MiR-486-5p, besides miR-486-3p, affects the erythroid differentiation further emphasizes the importance of miR-486-3p/miR-486-5p induction in MYBdependent control of erythropoiesis. (PMID:25857263)
• Circulating level of MIR486 was significantly higher in patients with acute myocardial infarction than in controls, especially NSTEMI. (PMID:26077801)
• The results suggest that miR-486 and miR-150 could be potential blood-based biomarkers for early diagnosis of non-small cell lung cancer. (PMID:26237047)
• miR-483-5p may play an important role in reducing insulin resistance, and miR-486-5p may promote cumulus cell proliferation through activation of PI3K/Akt. New insights into the mechanisms involved in PCOS by pathways possibly regulated by miRNAs. (PMID:26283014)
• Mir-486 regulates the ubiquitous proteasome by modulating Foxo1 activity during muscle atrophy. (PMID:26342566)
• we established that miR-486 and miR-92a in association with some high-density lipoprotein (HDL) components can designate vulnerable coronary artery disease patients. (PMID:26485305)
• This study investigated the expression level of miR-1, miR-486, and let-7a in 45 CN-AML patients well characterized for FLT3 and/or NPM1 mutations using real-time quantitative RT-PCR and evaluated the association between candidate miRs expression and clinical features (PMID:26526573)
• These data indicated that miR-486 aggravate the cholesterol accumulation in THP-1 cells by targeting HAT1. (PMID:26654953)
• These results suggested that MiR-486 mediated the hypoxia-induced angiogenic activity and promoted the proliferation and survival of BM-MSCs through regulating PTEN-PI3K/AKT signaling. (PMID:26801559)
• OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis. Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer. (PMID:26871282)
• MiR-486-5p might therefore be an independent tumor marker for evaluating prognosis in patients with esophageal squamous cell carcinomas or gastric adenocarcinomas (PMID:26895105)
• Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. (PMID:27133046)
• miR-486-5p induces papillary thyroid carcinoma cell growth inhibition and apoptosis by targeting and suppressing FBN1. (PMID:27133060)
• After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019). (PMID:27190129)
• After donor-specific HLA antibody production, miR-486-5p and its target PTEN/foxO3 mRNA were significantly overexpressed and underexpressed (p < 0.01), respectively, in patients with biopsy-proven chronic antibody-mediated rejection in kidney transplantation (PMID:27323802)
• High miR486 expression is associated with Hyperglycemic Acute Coronary Syndrome. (PMID:27519051)
• miR-486 regulates the erythroid differentiation of TF-1 and cord blood CD34+ cells via targeting Sirt1. (PMID:28043832)
• mir-486-5p is positively regulated by mir-660-5p in lung cancer cell lines, through the mir-660-MDM2-p53 pathway. (PMID:28124991)
• 6 microRNAs (miRNAs) hsa-mir-483-5p, hsa-mir-486-5p, hsa-30b-5p, hsa-mir-200a-3p, hsa-mir-502-3p and hsa-mir-142-3p are selected as most promising plasma biomarker candidates for the detection of early Alzheimer’s disease (AD). (PMID:28179587)
• TGFbeta/SMAD/miR-486-3p signaling axis in keratinocytes regulated K17 expression and cell proliferation. We conclude that the loss of miR-486-3p in psoriatic epidermis leads to K17 protein overexpression and contributes to the pathogenesis of psoriasis. (PMID:28642156)
• Comparison of MicroRNAs Mediated in Reactivation of the gamma-Globin in beta-Thalassemia Patients, Responders and Non-Responders to Hydroxyurea (PMID:28696844)
• MiR-486 role in the erythroid differentiation. (PMID:28733890)
• Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. (PMID:28924214)
• Study revealed that miR-486 was downregulated in esophageal squamous carcinoma and functions as a tumor suppressor by affecting cell proliferation, colony formation and apoptosis by targeting CDK4 and BCAS2. (PMID:29115564)
• MicroRNA-486-5p suppresses TGFB2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2. (PMID:29229876)
• We conclude that miR-486-5p stimulates cell proliferation, migration, and invasion through inhibition of PTEN expression and activation of the oncogenic PI3K/Akt pathway in cervical cancer. Our findings implicate serum miR-486-5p as a novel molecular biomarker that may provide effective approaches to both diagnosis and treatment in cervical cancer (PMID:29316891)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir486	ENSMUSG00000070084
rattus_norvegicus	rno-mir-486	ENSRNOG00000062490

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.