MIR486-2

Summary

MIR486-2 (microRNA 486-2, HGNC:50213) is a microRNA gene on chromosome 8p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465696 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50213
Approved symbol	MIR486-2
Name	microRNA 486-2
Location	8p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-486-2
Ensembl gene	ENSG00000283450
Ensembl biotype	miRNA
Entrez	102465696
RNAcentral	URS000075EE0E — miRNA, 64 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637446

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637446 — 1 exons

Exon	Start	End
ENSE00003794288	41660444	41660507

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 80.60.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	80.60	gold quality
body of stomach	UBERON:0001161	76.86	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.54	gold quality
right atrium auricular region	UBERON:0006631	69.93	gold quality
blood	UBERON:0000178	69.31	gold quality
heart left ventricle	UBERON:0002084	69.25	gold quality
anterior cingulate cortex	UBERON:0009835	67.76	gold quality
popliteal artery	UBERON:0002250	67.61	gold quality
esophagus mucosa	UBERON:0002469	67.40	gold quality
tibial artery	UBERON:0007610	66.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.09	gold quality
upper lobe of left lung	UBERON:0008952	64.91	gold quality
right frontal lobe	UBERON:0002810	64.23	gold quality
omental fat pad	UBERON:0010414	64.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.03	gold quality
amygdala	UBERON:0001876	63.58	gold quality
left lobe of thyroid gland	UBERON:0001120	61.77	gold quality
spleen	UBERON:0002106	60.69	gold quality
caudate nucleus	UBERON:0001873	59.04	gold quality
putamen	UBERON:0001874	58.70	gold quality
pituitary gland	UBERON:0000007	56.94	gold quality
left testis	UBERON:0004533	43.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• Exposure to high glucose increases miR-486-5p expression and inhibits SIRT1 expression in human adipose tissue-derived mesenchymal stem cells. (PMID:21988232)
• The MYB/MAF co-silencing constrained the skewing of erythroid versus megakaryocyte lineage commitment in MYB-silenced CD34+ cells, by restraining the expansion of megakaryocyte lineage while partially rescuing the impairment of erythropoiesis. (PMID:25857263)
• miR-483-5p may play an important role in reducing insulin resistance, and miR-486-5p may promote cumulus cell proliferation through activation of PI3K/Akt. New insights into the mechanisms involved in PCOS by pathways possibly regulated by miRNAs. (PMID:26283014)
• MiR-486-5p might therefore be an independent tumor marker for evaluating prognosis in patients with esophageal squamous cell carcinomas or gastric adenocarcinomas (PMID:26895105)
• Study shows that renal cell carcinoma (RCC) with low levels of miR-486 expression compared with normal tissues has a relatively poor prognosis, whereas high miR-486 expression is associated with a long survival rate in patients with RCC. miR-486 inhibits RCC cell proliferation and promotes apoptosis by targeting TAK1. (PMID:30537206)
• Study found that SIRT1 served as a direct target of miR486. The high expression of SIRT1 was involved in maintaining the selfrenewal and tumorigenic potential of liver cancer stemlike cells. (PMID:30569158)
• the XIST/miR-486 -5p/NRP-2 axis appeared to participate in the progression of colorectal cancer (PMID:30656681)
• Expression of miR-486-5p and its signi fi cance in lung squamous cell carcinoma. (PMID:30963622)
• Betel nut alkaloid may recruit DNMT3B to regulate miR-486-3p/DDR1 axis in oral cancer andmiR-486-3p and DDR1 may serve as potential therapeutic targets of oral cancer. (PMID:31253192)
• The miR-486-5p/KIAA1199/epithelial-mesenchymal transition axis might play a critical role in Papillary Thyroid Cancer invasion and metastasis. (PMID:31501407)
• MicroRNA-486-5p inhibits ovarian granulosa cell proliferation and participates in the development of PCOS via targeting MST4. (PMID:31539108)
• Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p. (PMID:32492708)
• Association between oxidative stress and microRNA expression pattern of ALS patients in the high-incidence area of the Kii Peninsula. (PMID:32739158)
• miRNA-486-5p Promotes COPD Progression by Targeting HAT1 to Regulate the TLR4-Triggered Inflammatory Response of Alveolar Macrophages. (PMID:33244226)
• Can miRNA Indicate Risk of Illness after Continuous Exposure to M. tuberculosis? (PMID:33916069)
• Exosomal miR-486-5p derived from human placental microvascular endothelial cells regulates proliferation and invasion of trophoblasts via targeting IGF1. (PMID:33977502)
• MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines. (PMID:34285285)
• miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1. (PMID:34395181)
• Serum microRNA-486-5p expression in obese Egyptian children and its possible association with fatty liver. (PMID:34509791)
• Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress. (PMID:34686196)
• miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection. (PMID:35077859)
• Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis. (PMID:37480032)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.