MIR487A

Summary

MIR487A (microRNA 487a, HGNC:32343) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 619555 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32343
Approved symbol	MIR487A
Name	microRNA 487a
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-487, hsa-mir-487a
Ensembl gene	ENSG00000207742
Ensembl biotype	miRNA
Entrez	619555
RNAcentral	URS000070BFF5 — miRNA, 80 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385009 — 1 exons

Exon	Start	End
ENSE00001500016	101052446	101052525

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 90.06.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	90.06	gold quality
lung	UBERON:0002048	84.70	gold quality
placenta	UBERON:0001987	81.75	gold quality
muscle of leg	UBERON:0001383	80.36	gold quality
monocyte	CL:0000576	78.71	gold quality
stomach	UBERON:0000945	76.55	gold quality
intestine	UBERON:0000160	75.53	gold quality
blood	UBERON:0000178	74.11	gold quality
heart	UBERON:0000948	73.05	gold quality
heart left ventricle	UBERON:0002084	72.03	gold quality
right atrium auricular region	UBERON:0006631	71.62	gold quality
endometrium	UBERON:0001295	69.51	gold quality
esophagus mucosa	UBERON:0002469	68.92	gold quality
right adrenal gland	UBERON:0001233	68.76	gold quality
colon	UBERON:0001155	68.75	gold quality
Ammon’s horn	UBERON:0001954	67.99	gold quality
ovary	UBERON:0000992	67.53	gold quality
left ovary	UBERON:0002119	67.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.38	gold quality
myometrium	UBERON:0001296	66.26	gold quality
body of stomach	UBERON:0001161	66.23	gold quality
body of pancreas	UBERON:0001150	65.12	gold quality
left adrenal gland	UBERON:0001234	64.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.96	gold quality
anterior cingulate cortex	UBERON:0009835	64.39	gold quality
left adrenal gland cortex	UBERON:0035825	64.31	gold quality
skin of abdomen	UBERON:0001416	64.09	gold quality
omental fat pad	UBERON:0010414	63.95	gold quality
cerebellar hemisphere	UBERON:0002245	63.83	gold quality
putamen	UBERON:0001874	63.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• miR-487a can directly regulate BCRP expression and reverse chemotherapeutic drug resistance in a subset of breast cancers. (PMID:23879965)
• Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC. (PMID:27827315)
• Study suggests that miR-487a-3p might repress CTLA4 and FOXO3 by binding to their 3’UTRs and contribute to the development of T1D. (PMID:29859273)
• The repression of TIA-1 by miR-487a promoted cell proliferation and suppressed cell apoptosis in vitro, and the knockdown of miR-487a had the opposite effects. (PMID:30144499)
• The knockdown of microRNA-487a significantly inhibited proliferative, migratory and invasive abilities of esophageal cancer cells but induced cell apoptosis. The protein expression of p62 was remarkably upregulated after microRNA-478a knockdown in esophageal cancer cells. (PMID:30840272)
• MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation possibly by upregulating miRNA-487a. (PMID:30988676)
• High miR487a expression is associated with osteosarcoma. (PMID:31111286)
• MicroRNA-487a-3p functions as a new tumor suppressor in prostate cancer by targeting CCND1. (PMID:31309555)
• miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer. (PMID:31820783)
• Tumor microRNAs Identified by Small RNA Sequencing as Potential Response Predictors in Locally Advanced Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy. (PMID:32345666)
• miR-487a performs oncogenic functions in osteosarcoma by targeting BTG2 mRNA. (PMID:32409840)
• MiR-487a-3p suppresses the malignant development of pancreatic cancer by targeting SMAD7. (PMID:32622014)
• Exosomal miR-487a derived from m2 macrophage promotes the progression of gastric cancer. (PMID:33522393)
• MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A. (PMID:33724144)
• lncRNA TSPEAR-AS2, a Novel Prognostic Biomarker, Promotes Oral Squamous Cell Carcinoma Progression by Upregulating PPM1A via Sponging miR-487a-3p. (PMID:34336002)
• The prognostic value of miR-487a in clear cell renal cell carcinoma and its influence on cell biological behavior. (PMID:35818915)

Cross-species orthologs

0 orthologs

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.