MIR487B

Summary

MIR487B (microRNA 487b, HGNC:32533) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 664616 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32533
Approved symbol	MIR487B
Name	microRNA 487b
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-487b
Ensembl gene	ENSG00000207754
Ensembl biotype	miRNA
OMIM	615037
Entrez	664616
RNAcentral	URS000075E150 — miRNA, 84 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385021

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385021 — 1 exons

Exon	Start	End
ENSE00001500028	101046455	101046538

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 92.30.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	92.30	gold quality
kidney	UBERON:0002113	91.79	gold quality
intestine	UBERON:0000160	86.27	gold quality
colon	UBERON:0001155	82.45	gold quality
stomach	UBERON:0000945	82.19	gold quality
lung	UBERON:0002048	80.49	gold quality
placenta	UBERON:0001987	79.34	gold quality
heart	UBERON:0000948	75.33	gold quality
blood	UBERON:0000178	74.55	gold quality
body of stomach	UBERON:0001161	71.76	gold quality
endometrium	UBERON:0001295	71.55	gold quality
body of pancreas	UBERON:0001150	70.93	gold quality
corpus callosum	UBERON:0002336	69.53	gold quality
left adrenal gland	UBERON:0001234	69.49	gold quality
prefrontal cortex	UBERON:0000451	67.99	gold quality
ovary	UBERON:0000992	67.54	gold quality
left ovary	UBERON:0002119	67.54	gold quality
urinary bladder	UBERON:0001255	67.33	gold quality
left adrenal gland cortex	UBERON:0035825	67.28	gold quality
omental fat pad	UBERON:0010414	66.98	gold quality
putamen	UBERON:0001874	66.81	gold quality
right atrium auricular region	UBERON:0006631	66.53	gold quality
Ammon’s horn	UBERON:0001954	66.03	gold quality
ascending aorta	UBERON:0001496	65.93	gold quality
liver	UBERON:0002107	65.21	gold quality
right adrenal gland	UBERON:0001233	65.18	gold quality
esophagus mucosa	UBERON:0002469	65.12	gold quality
hypothalamus	UBERON:0001898	64.92	gold quality
caudate nucleus	UBERON:0001873	64.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miR-487b is a tumor suppressor microRNA silenced by epigenetic mechanisms during tobacco-induced pulmonary carcinogenesis. (PMID:23426183)
• Mir-487b, mapped to the 14q32.31 locus, regulates proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID:24166498)
• Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). (PMID:24258346)
• Expression of maternal miR-487b and paternal miR-516a-5p improves the risk stratification in neuroblastoma. (PMID:24931722)
• Data show that in arterial endothelial cells, inhibition of miR-329, miR-487b, and miR-495 all led to increased cell proliferation by approximately 20%, 50%, and 35%, respectively, but inhibition of miR-494 did not affect endothelial cell proliferation. (PMID:25085941)
• miR-487b regulates angiogenesis by directly targeting THBS1 in HUVECs, indicating that miR-487b may contribute to angiogenesis and the functional recovery from ischemic stroke. (PMID:25660232)
• miR-487b-5p regulates temozolomide resistance of lung cancer cells through LAMP2-mediated autophagy. (PMID:27097129)
• The cluster 14q32.31 member miR-487b was variably under-expressed in pediatric glioma lines compared with human neural stem cells. Overexpression of miR-487b in a pediatric glioma cell line (KNS42) using lentiviral vectors led to a decrease in colony formation in soft agar (30%) (P<0.05), and decreased expression of known predicted targets PROM1 and Nestin (PMID:27739438)
• Our data suggest a possibility that miR-487b may suppress metastasis of colorectal cancer progression through inhibition of KRAS (PMID:28000854)
• Study found that miR-487b expression is decreased in colon cancer specimens. Its overexpression inhibits tumor growth in vivo. (PMID:28114282)
• In human primary cells, we confirmed the shift in miR487b targeting after editing, resulting in a edited miR487b targetome that is enriched for multiple proangiogenic pathways. miR487b is found in multiple human primary vascular cell types. The same adenosine residue is methylated in mice and human primary cells. (PMID:29284691)
• miR-487b can significantly mitigate the symptoms of allergic rhinitis by inhibiting the IL-33/ST2 signaling pathway. (PMID:30556842)
• we confirmed that miR-487b is a CRC suppressor that prevents the EMT process and targets MYC, SUZ12, and KRAS to inhibit the proliferation, migration and invasion of CRC cells. Meanwhile, miR-487b is negatively regulated by DNA methylation (PMID:30791232)
• miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer. (PMID:31820783)
• miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers. (PMID:32267991)
• MicroRNA487b3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3. (PMID:33125503)
• Clinical significance of serum miR-487b in HBV-related hepatocellular carcinoma and its potential mechanism. (PMID:33783293)
• Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children. (PMID:33876465)
• MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3. (PMID:35802304)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir487b	ENSRNOG00000036489

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.