MIR488

Summary

MIR488 (microRNA 488, HGNC:32073) is a microRNA gene on chromosome 1q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574441 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32073
Approved symbol	MIR488
Name	microRNA 488
Location	1q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-488
Ensembl gene	ENSG00000202609
Ensembl biotype	miRNA
Entrez	574441
RNAcentral	URS000072C8C2 — miRNA, 83 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000365739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365739 — 1 exons

Exon	Start	End
ENSE00001440502	177029363	177029445

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 72.08.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	72.08	gold quality
left adrenal gland cortex	UBERON:0035825	71.07	gold quality
tibial artery	UBERON:0007610	70.94	gold quality
ascending aorta	UBERON:0001496	66.95	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.11	gold quality
skin of leg	UBERON:0001511	63.25	gold quality
caudate nucleus	UBERON:0001873	62.42	gold quality
brain	UBERON:0000955	58.47	gold quality
cerebellum	UBERON:0002037	56.42	silver quality
liver	UBERON:0002107	54.47	gold quality
right testis	UBERON:0004534	48.91	gold quality
corpus callosum	UBERON:0002336	42.45	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 37)

• Functional studies revealed that miR-138-2, miR-148a, and miR-488 repress (30%-60%) several candidate genes for panic disorder-GABRA6, CCKBR and POMC. (PMID:21168126)
• Loss of miR 488 is associated with prostate carcinoma. (PMID:21710544)
• miR-488 acts as a positive role for chondrocyte differentiation/cartilage development by inhibiting MMP-13 activity through targeting ZIP-8. (PMID:23688035)
• miR-448 expression was downregulated in gastric cancer tissues compared with the corresponding nontumor tissues, and in cell lines. Ectopic expression of miR-448 suppressed GC cell proliferation, colony formation, and invasion. ADAM10 is a direct target gene of miR-448 in GC cells. Its expression was upregulated in GC tissues and cells, and correlated negatively with mirR-448 expression. (PMID:26852749)
• Our data suggest that miRNA-488 may serve as a predictor of response to chemotherapy and as a therapeutic target in human osteosarcomas. (PMID:27376839)
• miRNA-488 participates in eIF3a mediated cisplatin resistance in non-small-cell lung cance cells. (PMID:28074905)
• LncRNA PVT1 regulates chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR-488-3p. (PMID:28520497)
• the PHF8 oncogene is involved in the progression of CRC. The preliminary findings indicated that PHF8, as a potential target of miR-488, can be suppressed by the overexpression of miR-488. Low levels of miR-488 and high levels of PHF8 were correlated with poor overall survival rates in patients with CRC. (PMID:28765946)
• This study demonstrates the roles of miR-488 and miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of gouty arthritis (PMID:28915828)
• PVT1-miR-190a-5p/miR-488-3p-MEF2C-JAGGED1 axis is involved in proliferation and progression of glioma. Thus, PVT1 may become a novel target in glioma therapy. (PMID:29501773)
• Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients. (PMID:30061217)
• Overexpression of miR-488 suppresses cell proliferation in colorectal cancer cells. (PMID:30207785)
• this is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of Hirschsprung’s disease. (PMID:30443988)
• miR-488 promotes fracture healing by targeting DKK1 expression in osteoblasts. (PMID:30575941)
• PCYR1 expression is negatively regulated by miR-488, and up-regulation of miR-488 significantly inhibited tumorigenesis in non-small-cell lung cancer. (PMID:30605882)
• The enhancement of circ_0020123 in tumor tissues correlated with positive lymph node metastasis, advanced TNM stages, and adverse prognosis for NSCLC patients. For the mechanism exploration, circ_0020123 could sponge miR-488-3p to release its inhibition on ADAM9 expression. (PMID:31153639)
• MicroRNA-488 regulates diabetic nephropathy via TGF-beta1 pathway. (PMID:31173306)
• MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma. (PMID:31243806)
• LncRNA SNHG1 overexpression regulates the proliferation of acute myeloid leukemia cells through miR-488-5p/NUP205 axis. (PMID:31298340)
• miR-488 inhibits prostate cancer cell proliferation and glycolysis by targeting PFKFB3, and thus, miR-488 may be a novel therapeutic candidate for prostate cancer (PMID:31410981)
• miR-488 mediates negative regulation of the AKT/NF-kappaB pathway by targeting Rac1 in LPS-induced inflammation. (PMID:31674024)
• These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue. (PMID:31765608)
• MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression. (PMID:32271408)
• Higher Peripheral Blood MiR-488 Level Predicts Poor Prognosis of Acute Ischemic Stroke. (PMID:32658439)
• Mir-488 alleviates chemoresistance and glycolysis of colorectal cancer by targeting PFKFB3. (PMID:32990355)
• Downregulation of Long Noncoding RNA Myocardial Infarction Associated Transcript Suppresses Cell Proliferation, Migration, Invasion, and Glycolysis by Regulation of miR-488-3p/IGF1R Pathway in Colorectal Cancer. (PMID:33085926)
• MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas. (PMID:33099573)
• LncRNA HOTAIR Influences the Growth, Migration, and Invasion of Papillary Thyroid Carcinoma via Affection on the miR-488-5p/NUP205 Axis. (PMID:33107391)
• MicroRNA-488 serves as a diagnostic marker for atherosclerosis and regulates the biological behavior of vascular smooth muscle cells. (PMID:34288824)
• Circular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation. (PMID:34565283)
• LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling. (PMID:34595994)
• [Down-regulation of miR-488 targeting to promote Jag1 expression inhibits hypoxia-reoxygenation myocardial H9c2 cell damage]. (PMID:34839506)
• The NF-kappaB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling. (PMID:35343383)
• Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer. (PMID:36449143)
• Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer. (PMID:36624091)
• miR-488-3p Represses Malignant Behaviors and Facilitates Autophagy of Osteosarcoma Cells by Targeting Neurensin-2. (PMID:37365792)
• MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases. (PMID:37418982)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir488	ENSMUSG00000070103
rattus_norvegicus	Mir488	ENSRNOG00000036265

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.