MIR490

Summary

MIR490 (microRNA 490, HGNC:32075) is a microRNA gene on chromosome 7q33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574443 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32075
Approved symbol	MIR490
Name	microRNA 490
Location	7q33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-490, miR-490
Ensembl gene	ENSG00000207597
Ensembl biotype	miRNA
OMIM	616972
Entrez	574443
RNAcentral	URS00006E154A — miRNA, 128 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384865

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384865 — 1 exons

Exon	Start	End
ENSE00001499872	136903167	136903294

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 67.68.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
substantia nigra	UBERON:0002038	67.68	gold quality
urinary bladder	UBERON:0001255	67.00	gold quality
skin of leg	UBERON:0001511	65.79	gold quality
esophagus	UBERON:0001043	64.76	gold quality
upper lobe of left lung	UBERON:0008952	64.25	gold quality
putamen	UBERON:0001874	63.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.80	gold quality
left uterine tube	UBERON:0001303	63.71	gold quality
heart	UBERON:0000948	63.51	gold quality
caudate nucleus	UBERON:0001873	63.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.47	gold quality
heart left ventricle	UBERON:0002084	63.08	gold quality
intestine	UBERON:0000160	62.27	gold quality
right atrium auricular region	UBERON:0006631	62.20	gold quality
colon	UBERON:0001155	62.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.54	gold quality
stomach	UBERON:0000945	60.73	gold quality
hypothalamus	UBERON:0001898	59.06	gold quality
anterior cingulate cortex	UBERON:0009835	58.97	gold quality
body of stomach	UBERON:0001161	58.65	gold quality
transverse colon	UBERON:0001157	58.51	gold quality
lung	UBERON:0002048	58.21	gold quality
right frontal lobe	UBERON:0002810	52.53	gold quality
right testis	UBERON:0004534	47.49	gold quality
left testis	UBERON:0004533	45.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Data shsow that miR-363, miR-490, miR-137, miR-217 and miR-4792 were the top five significantly de-regulated miRNAs in uterine leiomyoma (ULM). (PMID:22446413)
• A developmentally restricted function of miR-490 and its putative DAAM1 target are associated with exaggerated megakaryocytopoiesis and/or proplatelet formation. (PMID:22869791)
• miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). (PMID:23212913)
• inhibition of miR0-490-3p up-regulated its target gene PAPP-A and then increased the proteolysis of IGFBP-4 (PMID:23821525)
• These findings indicate miR-490-5p to be a novel tumor suppressor of bladder cancer cell proliferation through targeting c-Fos. (PMID:24220339)
• forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1, which plays a key role in G1/S phase transition (PMID:24440705)
• The levels of urinary miR-490 are associated with FSGS disease activity (PMID:25107948)
• microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells. (PMID:25297343)
• miR-490-3P transfection suppressed tumor development and CDK1, Bcl-xL, MMP2/9 expression while inducing P53 expression. These findings indicate that miR-490-3P may target CDK1 and inhibit ovarian epithelial carcinoma tumorigenesis and progression. (PMID:25819031)
• MiR-490 significantly inhibits the replication and expression of coxsackievirus B3. (PMID:25868275)
• Results suggest that microRNA miR-490-3p functions as a potential tumor suppressor by down-regulating high-mobility group protein HMGA2 expression directly. (PMID:26341146)
• miR-490-5p functions as a tumour suppressor in renal carcinoma by targeting PIK3CA (PMID:26559013)
• Results show that miR-490-3p is downregulated during colorectal cancer (CRC) progression. It represses CRC cell migration and invasion abilities, partially by targeting to the TGF-beta signaling pathway which suggests it as a tumor suppressor in CRC. (PMID:26714817)
• The CCAT1/miR-490/hnRNPA1 axis promotes gastric cancer migration, and it may have a possible diagnostic and therapeutic potential in gastric cancer. (PMID:26825578)
• This is the first demonstration that miR-490-3P might act as a suppressor in endometrial cancer tumorigenesis and progression by targeting TGFalpha. (PMID:26843615)
• Suggest that the miR-490-3p/FRAT1/beta-catenin axis is important in colorectal cancer progression. (PMID:27037061)
• The tumor suppressive activity of miR-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin signaling. Thus, miR-490-3p may represent a potential therapeutic target for triple-negative breast cancer. (PMID:27506313)
• High expression of miR490 is associated with lung cancer metastasis. (PMID:27683057)
• colon cancer-associated transcript 1/miR-490-3p/cyclin-dependent kinase 1 regulatory pathway promotes the progression of hepatocellular carcinoma. (PMID:28381168)
• It has been suggested that through interaction with miR-490-3p DLEU1 may influence the expression of CDK1, CCND1 and SMARCD1 protein, subsequently promoting the development and progression of ovarian carcinoma. (PMID:28598010)
• miR-490-3p is a promising prognostic biomarker for Helicobacter pylori positive gastric cancer (PMID:28829504)
• Low miR490 expression is associated with Hepatocellular Carcinoma Cell Proliferation, Migration and Invasion. (PMID:28924964)
• Low miR490 expression is associated with hepatocellular carcinoma. (PMID:29676845)
• Colorectal carcinoma (CRC) patients with elevated miR4903p amounts had prolonged overall survival. Ectopic expression of miR4903p in CRC cells resulted in decreased expression of RAB14, which was directly targeted by miR4903p, interacting with its 3’UTR. (PMID:29916545)
• MiR-490-5p inhibits the metastasis of hepatocellular carcinoma by down-regulating E2F2 and ECT2. (PMID:29932246)
• Involved in clear cell renal carcinoma vasculogenic mimicry and metastasis through association with TR4 nuclear receptor and vimentin (PMID:29973687)
• Auithors found that miR-490-3p is down-regulated in HCC and is related to genes that have potential tumoral functions. (PMID:30007991)
• Twist-related protein 1 (TWIST1) was a target of miR-490-3p and participated in long non-coding RNA TP73 antisense RNA 1 (TP73-AS1)/miR-490-3p-modulated MDA-MB-231cell vasculogenic mimicry (VM) formation. (PMID:30193732)
• MiR-490-5p repressed the sphere formation ability, stemness, and proliferation of hepatocellular carcinoma cells through inhibiting the expression of ECT2. (PMID:30206962)
• MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1 (PMID:30262997)
• our findings demonstrated that low expression of miR-490-3p or high expression of PPM1F was positively associated with poor survival and tumor recurrence in patients with HCC, and miR-490-3p suppressed cell proliferation and invasion by targeting PPM1F. (PMID:30470261)
• miR-490-3p inhibits the proliferation, migration, invasion and epithelial mesenchymal transformation of esophageal squamous carcinoma cells by target regulating HMGA2 expression. (PMID:30556870)
• Overexpression of microRNA-490-3p alleviates inflammation and apoptosis via targeting MK2, thereafter promoting spinal cord injury recovery. (PMID:30575927)
• miR-490-3p modulates the progression of prostate cancer through regulating histone deacetylase 2. (PMID:30720161)
• Expressions of Linc00299 and miR-490-3p were upregulated and downregulated in atherosclerosis patients, respectively. (PMID:30734057)
• Akirin2 expression is negatively controlled by miR-490-3p in cholangiocarcinoma (CCA) cells, and miR-490-3p attenuated cell migration and angiogenesis in CCA cells by silencing Akirin2. (PMID:30886152)
• The overexpression of MAP3K9 could promote cell viability, migration and invasion rates, EMT process and ability of cloning, miR4905p could target MAP3K9 and further modulate the proliferation, migration, invasion and EMT of pharyngolaryngeal cancer cells. (PMID:31115491)
• Up-regulation of SNHG15 was found in hepatocellular carcinoma (HCC) and was related to aggressive behaviors in HCC patients. Knockdown of SNHG15 restrained HCC cell proliferation, migration and invasion. SNHG15 served as a molecular sponge for miR-490-3p which directly targets HDAC2. HDAC2 was involved in HCC progression by interacting with the SNHG15/miR-490-3p axis. (PMID:31636472)
• lncRNA XLOC_001659 knockdown inhibits proliferation and invasion of esophageal squamous cell carcinoma cells via regulation of miR-490-5p/PIK3CA, suggesting that it may play a role in ESCC tumorigenesis and progression (PMID:31754291)
• lncRNA CCAT1/miR-490-3p/MAPK1/c-Myc positive feedback loop drives progression of acute myeloid leukaemia. (PMID:31790145)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir490	ENSMUSG00000070075
rattus_norvegicus	Mir490	ENSRNOG00000036272

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.