MIR497HG

Summary

MIR497HG (mir-497-195 cluster host gene, HGNC:39523) is a long non-coding RNA gene on chromosome 17p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39523
Approved symbol	MIR497HG
Name	mir-497-195 cluster host gene
Location	17p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MIR195HG
Ensembl gene	ENSG00000267532
Ensembl biotype	lncRNA
Entrez	100506755
RNAcentral	URS000075E9D2 — lncRNA, 794 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 61 — 61 lncRNA

ENST00000399540, ENST00000399541, ENST00000443997, ENST00000570562, ENST00000571010, ENST00000572385, ENST00000572453, ENST00000572547, ENST00000573222, ENST00000573755, ENST00000573939, ENST00000574377, ENST00000575727, ENST00000575889, ENST00000653385, ENST00000654550, ENST00000659173, ENST00000659418, ENST00000666062, ENST00000667870, ENST00000715686, ENST00000715687, ENST00000772048, ENST00000772049, ENST00000772050, ENST00000772051, ENST00000772052, ENST00000772053, ENST00000772054, ENST00000772055, ENST00000772056, ENST00000772057, ENST00000772058, ENST00000772059, ENST00000772060, ENST00000772061, ENST00000772062, ENST00000772063, ENST00000772064, ENST00000772065, ENST00000772066, ENST00000772067, ENST00000772068, ENST00000772069, ENST00000772070, ENST00000772071, ENST00000772072, ENST00000772073, ENST00000772074, ENST00000772075, ENST00000772076, ENST00000772077, ENST00000772078, ENST00000772079, ENST00000772080, ENST00000772081, ENST00000772082, ENST00000772083, ENST00000772084, ENST00000772085, ENST00000772086

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399540 — 3 exons

Exon	Start	End
ENSE00003464135	7009796	7009889
ENSE00004135613	7012196	7012349
ENSE00004135673	7001132	7002620

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 92.64.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7193 / max 19.9269, expressed in 304 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164078	6.5468	1719
164085	0.7193	304
164077	0.5091	203

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	92.64	gold quality
descending thoracic aorta	UBERON:0002345	91.98	gold quality
thoracic aorta	UBERON:0001515	91.81	gold quality
ascending aorta	UBERON:0001496	91.78	gold quality
left coronary artery	UBERON:0001626	90.29	gold quality
right adrenal gland cortex	UBERON:0035827	89.61	gold quality
left adrenal gland cortex	UBERON:0035825	89.55	gold quality
right adrenal gland	UBERON:0001233	88.89	gold quality
popliteal artery	UBERON:0002250	88.86	gold quality
tibial artery	UBERON:0007610	88.84	gold quality
left adrenal gland	UBERON:0001234	88.66	gold quality
adrenal gland	UBERON:0002369	88.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.82	gold quality
myometrium	UBERON:0001296	87.46	gold quality
putamen	UBERON:0001874	87.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.79	gold quality
left ovary	UBERON:0002119	86.77	gold quality
lower esophagus	UBERON:0013473	86.70	gold quality
caudate nucleus	UBERON:0001873	86.67	gold quality
ovary	UBERON:0000992	86.60	gold quality
right ovary	UBERON:0002118	86.47	gold quality
body of uterus	UBERON:0009853	86.14	gold quality
Ammon’s horn	UBERON:0001954	85.89	gold quality
anterior cingulate cortex	UBERON:0009835	85.39	gold quality
endocervix	UBERON:0000458	85.19	gold quality
amygdala	UBERON:0001876	85.16	gold quality
left uterine tube	UBERON:0001303	85.01	gold quality
temporal lobe	UBERON:0001871	85.00	gold quality
nucleus accumbens	UBERON:0001882	84.69	gold quality
substantia nigra	UBERON:0002038	84.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR497/MIR497HG inhibits glioma cell proliferation by targeting CCNE1 and the miR588/TUSC1 axis. (PMID:34664678)
• The mechanism and therapeutic potential of lncRNA MIR497HG/miR-16-5p axis in breast cancer. (PMID:38956558)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.