MIR498

Summary

MIR498 (microRNA 498, HGNC:32092) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574460 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32092
Approved symbol	MIR498
Name	microRNA 498
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-498
Ensembl gene	ENSG00000207869
Ensembl biotype	miRNA
OMIM	620584
Entrez	574460
RNAcentral	URS00006C7250 — miRNA, 124 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385134

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385134 — 1 exons

Exon	Start	End
ENSE00001500140	53674197	53674320

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 80.37.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	80.37	gold quality
blood	UBERON:0000178	80.36	gold quality
lung	UBERON:0002048	76.00	gold quality
monocyte	CL:0000576	75.55	gold quality
tibial nerve	UBERON:0001323	73.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.37	gold quality
ascending aorta	UBERON:0001496	69.00	gold quality
left adrenal gland cortex	UBERON:0035825	67.84	gold quality
right atrium auricular region	UBERON:0006631	66.47	gold quality
vagina	UBERON:0000996	66.37	gold quality
left ovary	UBERON:0002119	66.23	gold quality
right frontal lobe	UBERON:0002810	65.10	gold quality
minor salivary gland	UBERON:0001830	64.49	gold quality
esophagus mucosa	UBERON:0002469	64.17	gold quality
transverse colon	UBERON:0001157	63.26	gold quality
left lobe of thyroid gland	UBERON:0001120	62.10	gold quality
spleen	UBERON:0002106	61.95	gold quality
left testis	UBERON:0004533	48.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• mir498 has a role in 1,25-Dihydroxyvitamin D3 suppression of telomerase expression and cancer growth (PMID:23055531)
• host-encoded miR-498 and miR-320d regulated HSV-1 induction of KSHV lytic replication by targeting RTA (PMID:23418466)
• down regulation of miR-498 in colorectal cancer tissues and the direct suppressive cellular effect noted in cancer cell lines implies that miR-498 has some direct or indirect role in the pathogenesis of colorectal adenocarcinomas. (PMID:25128149)
• studies suggest that miR-498-mediated hTERT downregulation is a key event mediating the anti-leptin activity of 1,25(OH)2D3 in estrogen-sensitive tumors in women (PMID:25252917)
• miR-498 acted as a new tumor suppressor by targeting the FOXO3 gene and inhibiting cell proliferation of ovarian cancer. (PMID:26054675)
• MicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progression (PMID:26323905)
• Decreased miR-498 expression levels correlated well with FIGO stage, tumour grade and lymph node metastases, shorter overall and progression-free survival in ovarian cancer patients. (PMID:26744867)
• High expression level of miR498 is associated with triple negative breast cancer. (PMID:26933805)
• MIR20b, MIR498 and MIR196 are involved in both apoptosis and autophagy processes in esophageal squamous cell carcinoma (PMID:27462775)
• Reduced expression of miR-498 in esophageal squamous cell carcinoma and in vitro analysis have confirmed the tumor suppressor properties of miR-498 by modulating the FOXO1/KLF6 signaling pathway. (PMID:28188753)
• MIRN498 promotes cell proliferation and inhibits cell apoptosis in retinoblastoma cell lines by directly targeting CCPG1. (PMID:29247256)
• miR-498 may serve as a tumor suppressor in NSCLC through targeting HMGA2. (PMID:29630114)
• overexpression of miR-498 suppresses Th17 cell differentiation by targeting STAT3 in rheumatoid arthritis patients (PMID:29691581)
• Bioinformatics analysis showed that miR-498 contained the complementary binding region of hsa_circRNA_100833 (identified as circFADS2), which was confirmed by Dual-luciferase reporter assay. In addition, the expression of miR-498 was down-regulated and negatively associated with circFADS2 expression in non small cell lung cancer. (PMID:29700215)
• UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy. (PMID:29970131)
• miR-498 directly targeted the 3’untranslated region of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mRNA and reduced PTEN protein levels in Triple negative breast cancer cells. (PMID:29985991)
• miR-498 can effectively suppress TIM-3 expression in the acute myeloid leukemia cell line (PMID:30107988)
• Study demonstrated that miR498 suppresses the growth and metastasis of liver cancer cells, partly at least, by directly targeting ZEB2, suggesting that miR498 may serve as a potential biomarker for the diagnosis and therapy of liver cancer. (PMID:30592286)
• Our study demonstrated that TMS reduced gefitinib resistance in NSCLCs via suppression of the MAPK/Akt/Bcl-2 pathway by upregulation of miR-345/498. (PMID:30701693)
• the miR-498 was found to target the 3’-UTR of lncRNA CASC11 and FOXK1 mRNA. (PMID:31121483)
• down-regulation of miR-498 was negatively related to circFADS2 and mTOR expression in LPS-treated chondrocytes (PMID:31141496)
• Up-regulation of miR-498 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting FOXO3. (PMID:31208923)
• aberrant expression of miR-498 changed the expression levels of phosphatase and tensin homolog and p-AKT in LNCaP and DU-145 PCa cells. (PMID:31332950)
• Low miR498 expression is associated with invasion of cervical cancer. (PMID:31445025)
• TUG1 downregulation constrains cell proliferation and invasion through regulating CDC42 expression via miR-498 in esophageal squamous cell carcinoma cells (PMID:32139664)
• Down-regulation of long non-coding RNA DUXAP8 suppresses proliferation, metastasis and EMT by modulating miR-498 through TRIM44-mediated AKT/mTOR pathway in non-small-cell lung cancer. (PMID:32271433)
• Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis. (PMID:32541093)
• miR-498/DNMT3b Axis Mediates Resistance to Radiotherapy in Esophageal Cancer Cells. (PMID:33885332)
• Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis. (PMID:34096776)
• miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3. (PMID:34114479)
• Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma. (PMID:34187214)
• Knockdown of MIR93HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR498 via EP300. (PMID:34468010)
• miR-498 Targets UBE2T to Inhibit the Proliferation of Malignant Melanoma Cells. (PMID:35243940)
• LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR-498-3p and targeting histone deacetylase 4. (PMID:35616349)
• Hsa_circ_0079480 enhances cell proliferation, migration, and invasion in colorectal cancer through miR-498/ATP5E axis. (PMID:36625260)
• Wilms’ tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p. (PMID:37667197)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.