MIR4999

Summary

MIR4999 (microRNA 4999, HGNC:43494) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847049 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43494
Approved symbol	MIR4999
Name	microRNA 4999
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4999
Ensembl gene	ENSG00000265390
Ensembl biotype	miRNA
Entrez	100847049
RNAcentral	URS000075A513 — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585029

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585029 — 1 exons

Exon	Start	End
ENSE00002717627	8389290	8389380

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 80.37.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	80.37	gold quality
bone marrow	UBERON:0002371	79.05	gold quality
blood	UBERON:0000178	77.35	gold quality
adrenal tissue	UBERON:0018303	77.21	gold quality
monocyte	CL:0000576	75.74	gold quality
islet of Langerhans	UBERON:0000006	74.87	gold quality
muscle of leg	UBERON:0001383	73.86	gold quality
gastrocnemius	UBERON:0001388	73.24	gold quality
adult mammalian kidney	UBERON:0000082	72.25	gold quality
stomach	UBERON:0000945	72.23	gold quality
liver	UBERON:0002107	72.23	gold quality
heart left ventricle	UBERON:0002084	71.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.09	gold quality
body of pancreas	UBERON:0001150	70.64	gold quality
body of stomach	UBERON:0001161	70.51	gold quality
rectum	UBERON:0001052	70.27	gold quality
heart	UBERON:0000948	70.17	gold quality
ascending aorta	UBERON:0001496	70.06	gold quality
left adrenal gland cortex	UBERON:0035825	69.78	gold quality
nucleus accumbens	UBERON:0001882	69.73	gold quality
tibial artery	UBERON:0007610	69.72	gold quality
popliteal artery	UBERON:0002250	69.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.17	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.02	gold quality
left adrenal gland	UBERON:0001234	68.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.68	gold quality
right lobe of liver	UBERON:0001114	68.45	gold quality
right atrium auricular region	UBERON:0006631	68.17	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.