MIR499B

Summary

MIR499B (microRNA 499b, HGNC:41640) is a microRNA gene on chromosome 20q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616134 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41640
Approved symbol	MIR499B
Name	microRNA 499b
Location	20q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-499a
Ensembl gene	ENSG00000283441
Ensembl biotype	miRNA
Entrez	100616134
RNAcentral	URS000075A7FA — miRNA, 73 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636498

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636498 — 1 exons

Exon	Start	End
ENSE00003797082	34990400	34990472

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 76.99.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	76.99	gold quality
heart left ventricle	UBERON:0002084	73.53	gold quality
gastrocnemius	UBERON:0001388	72.41	gold quality
cerebellar hemisphere	UBERON:0002245	72.32	gold quality
Ammon’s horn	UBERON:0001954	71.49	gold quality
anterior cingulate cortex	UBERON:0009835	71.02	gold quality
blood	UBERON:0000178	70.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.64	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.31	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.94	gold quality
transverse colon	UBERON:0001157	67.08	gold quality
hypothalamus	UBERON:0001898	67.00	gold quality
skin of leg	UBERON:0001511	66.94	gold quality
amygdala	UBERON:0001876	66.89	gold quality
substantia nigra	UBERON:0002038	63.80	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.22	gold quality
right frontal lobe	UBERON:0002810	58.67	gold quality
nucleus accumbens	UBERON:0001882	57.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The present study indicates that miRNA-499 rs3746444 polymorphism is associated with inflammatory arthritis susceptibility. However, there is lack of association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility. But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East. (PMID:31223622)
• Results find that miR-499 is one of the miRNA regulating PDCD4 expression in head and neck squamous cell carcinoma. Furthermore, the efficiency of miR-499 targeting PDCA4 is increased by the presence of both an intact miR-21 binding site and high levels of miR-21. (PMID:31235478)
• Data found that increased plasma levels of miR-208b and miR-499 were significantly associated with coronary artery disease (CAD) severity. Plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD. (PMID:31885748)
• Diagnostic value of circulating miR-208b and miR-499 in peripheral blood of patients with acute myocardial infarction. (PMID:32495615)
• Role of miRNA-499-5p in patients with atrial fibrillation and heart failure. (PMID:32693568)
• MicroRNA variants in endometriosis and its severity. (PMID:33583336)
• MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway. (PMID:34730202)
• Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis. (PMID:35358276)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.