MIR5000

Summary

MIR5000 (microRNA 5000, HGNC:43464) is a microRNA gene on chromosome 2p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100846995 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43464
Approved symbol	MIR5000
Name	microRNA 5000
Location	2p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5000
Ensembl gene	ENSG00000263909
Ensembl biotype	miRNA
Entrez	100846995
RNAcentral	URS000075C735 — ncRNA, 103 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577717

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577717 — 1 exons

Exon	Start	End
ENSE00002724980	75090812	75090914

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 97.57.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	97.57	gold quality
adult mammalian kidney	UBERON:0000082	83.87	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.80	gold quality
kidney	UBERON:0002113	79.77	gold quality
calcaneal tendon	UBERON:0003701	79.20	gold quality
stomach	UBERON:0000945	78.70	gold quality
monocyte	CL:0000576	77.09	gold quality
body of pancreas	UBERON:0001150	76.11	gold quality
blood	UBERON:0000178	75.83	gold quality
gastrocnemius	UBERON:0001388	74.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.37	gold quality
lung	UBERON:0002048	73.71	gold quality
left uterine tube	UBERON:0001303	72.70	gold quality
heart left ventricle	UBERON:0002084	72.23	gold quality
putamen	UBERON:0001874	71.99	gold quality
intestine	UBERON:0000160	71.35	gold quality
caudate nucleus	UBERON:0001873	71.29	gold quality
heart	UBERON:0000948	70.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.53	gold quality
right coronary artery	UBERON:0001625	70.26	gold quality
colon	UBERON:0001155	70.10	gold quality
ascending aorta	UBERON:0001496	69.93	gold quality
smooth muscle tissue	UBERON:0001135	69.87	gold quality
left coronary artery	UBERON:0001626	69.83	gold quality
right adrenal gland	UBERON:0001233	69.73	gold quality
myometrium	UBERON:0001296	69.72	gold quality
left adrenal gland	UBERON:0001234	69.30	gold quality
saliva-secreting gland	UBERON:0001044	68.90	gold quality
amygdala	UBERON:0001876	68.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Study showd three microRNAs miR-5000-3p, miR-5009-3P and miR-552 were found to be upregulated in side population cells of colon cancer cell lines . (PMID:24898979)
• E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis. (PMID:32094308)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.