MIR5001

Summary

MIR5001 (microRNA 5001, HGNC:43462) is a microRNA gene on chromosome 2q37.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847037 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43462
Approved symbol	MIR5001
Name	microRNA 5001
Location	2q37.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5001
Ensembl gene	ENSG00000284407
Ensembl biotype	miRNA
Entrez	100847037
RNAcentral	URS000075AC79 — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580185

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580185 — 1 exons

Exon	Start	End
ENSE00002702452	232550474	232550573

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 99.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3696 / max 59.3320, expressed in 1542 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
34565	6.3696	1542

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.28	gold quality
fundus of stomach	UBERON:0001160	77.56	gold quality
muscle of leg	UBERON:0001383	76.82	gold quality
gastrocnemius	UBERON:0001388	76.70	gold quality
right ovary	UBERON:0002118	73.64	gold quality
left uterine tube	UBERON:0001303	72.71	gold quality
bone marrow	UBERON:0002371	72.63	gold quality
blood	UBERON:0000178	72.51	gold quality
body of stomach	UBERON:0001161	71.33	gold quality
prefrontal cortex	UBERON:0000451	71.02	gold quality
smooth muscle tissue	UBERON:0001135	70.40	gold quality
urinary bladder	UBERON:0001255	70.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.29	gold quality
heart left ventricle	UBERON:0002084	69.96	gold quality
right adrenal gland	UBERON:0001233	69.54	gold quality
body of pancreas	UBERON:0001150	69.02	gold quality
endometrium	UBERON:0001295	68.62	gold quality
left adrenal gland	UBERON:0001234	68.11	gold quality
myometrium	UBERON:0001296	67.73	gold quality
left adrenal gland cortex	UBERON:0035825	67.68	gold quality
right lobe of thyroid gland	UBERON:0001119	67.40	gold quality
tonsil	UBERON:0002372	67.05	gold quality
lower esophagus	UBERON:0013473	67.04	gold quality
omental fat pad	UBERON:0010414	66.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.92	gold quality
ascending aorta	UBERON:0001496	66.85	gold quality
endocervix	UBERON:0000458	66.76	gold quality
right atrium auricular region	UBERON:0006631	66.73	gold quality
esophagus	UBERON:0001043	66.68	gold quality
colon	UBERON:0001155	66.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The miRNAs 203a/210-3p/5001-5p regulate the androgen/androgen receptor/YAP-induced migration in prostate cancer cells. (PMID:39149855)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.