MIR5002

Summary

MIR5002 (microRNA 5002, HGNC:43470) is a microRNA gene on chromosome 3q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847021 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43470
Approved symbol	MIR5002
Name	microRNA 5002
Location	3q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5002
Ensembl gene	ENSG00000266383
Ensembl biotype	miRNA
Entrez	100847021
RNAcentral	URS000075A3DC — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584713

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584713 — 1 exons

Exon	Start	End
ENSE00002686674	124132929	124133025

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 85.60.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	85.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.48	gold quality
kidney	UBERON:0002113	82.26	gold quality
stomach	UBERON:0000945	79.69	gold quality
liver	UBERON:0002107	79.49	gold quality
lung	UBERON:0002048	74.13	gold quality
gastrocnemius	UBERON:0001388	72.40	gold quality
heart	UBERON:0000948	72.34	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.20	gold quality
body of pancreas	UBERON:0001150	70.89	gold quality
left coronary artery	UBERON:0001626	70.88	gold quality
ascending aorta	UBERON:0001496	70.81	gold quality
thoracic aorta	UBERON:0001515	70.81	gold quality
calcaneal tendon	UBERON:0003701	70.76	gold quality
descending thoracic aorta	UBERON:0002345	70.63	gold quality
islet of Langerhans	UBERON:0000006	70.54	gold quality
body of stomach	UBERON:0001161	70.44	gold quality
tibial artery	UBERON:0007610	69.62	gold quality
heart left ventricle	UBERON:0002084	69.58	gold quality
amygdala	UBERON:0001876	69.43	gold quality
intestine	UBERON:0000160	69.35	gold quality
body of uterus	UBERON:0009853	69.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.66	gold quality
omental fat pad	UBERON:0010414	68.45	gold quality
right atrium auricular region	UBERON:0006631	68.35	gold quality
endometrium	UBERON:0001295	68.33	gold quality
right adrenal gland	UBERON:0001233	68.30	gold quality
left adrenal gland	UBERON:0001234	68.26	gold quality
substantia nigra	UBERON:0002038	68.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.