MIR5003

Summary

MIR5003 (microRNA 5003, HGNC:43512) is a microRNA gene on chromosome 5q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847029 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43512
Approved symbol	MIR5003
Name	microRNA 5003
Location	5q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5003
Ensembl gene	ENSG00000265160
Ensembl biotype	miRNA
Entrez	100847029
RNAcentral	URS000075A1B0 — ncRNA, 99 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581891

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581891 — 1 exons

Exon	Start	End
ENSE00002711981	172662165	172662263

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 92.42.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.42	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.11	gold quality
stomach	UBERON:0000945	78.00	gold quality
calcaneal tendon	UBERON:0003701	76.74	gold quality
adrenal tissue	UBERON:0018303	74.21	gold quality
muscle of leg	UBERON:0001383	74.01	gold quality
gastrocnemius	UBERON:0001388	73.16	gold quality
monocyte	CL:0000576	72.44	gold quality
fundus of stomach	UBERON:0001160	72.25	gold quality
corpus callosum	UBERON:0002336	71.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.84	gold quality
left coronary artery	UBERON:0001626	70.80	gold quality
heart	UBERON:0000948	70.63	gold quality
endometrium	UBERON:0001295	70.13	gold quality
blood	UBERON:0000178	69.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.85	gold quality
right atrium auricular region	UBERON:0006631	69.64	gold quality
heart left ventricle	UBERON:0002084	69.63	gold quality
body of pancreas	UBERON:0001150	69.61	gold quality
intestine	UBERON:0000160	69.40	gold quality
caudate nucleus	UBERON:0001873	69.23	gold quality
colon	UBERON:0001155	69.16	gold quality
kidney	UBERON:0002113	68.76	gold quality
right adrenal gland	UBERON:0001233	68.75	gold quality
transverse colon	UBERON:0001157	68.68	gold quality
tibial artery	UBERON:0007610	68.36	gold quality
left adrenal gland cortex	UBERON:0035825	68.30	gold quality
skin of leg	UBERON:0001511	68.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.20	gold quality
ascending aorta	UBERON:0001496	68.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.