MIR5006

Summary

MIR5006 (microRNA 5006, HGNC:43495) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847026 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43495
Approved symbol	MIR5006
Name	microRNA 5006
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5006
Ensembl gene	ENSG00000284584
Ensembl biotype	miRNA
Entrez	100847026
RNAcentral	URS000075DA5C — ncRNA, 110 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583027

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583027 — 1 exons

Exon	Start	End
ENSE00002720721	41568286	41568395

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 72.49.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	72.49	gold quality
substantia nigra	UBERON:0002038	68.94	gold quality
body of pancreas	UBERON:0001150	68.76	gold quality
heart left ventricle	UBERON:0002084	68.52	gold quality
body of stomach	UBERON:0001161	68.45	gold quality
right lobe of liver	UBERON:0001114	68.44	gold quality
thoracic aorta	UBERON:0001515	67.42	gold quality
ascending aorta	UBERON:0001496	67.08	gold quality
blood	UBERON:0000178	66.63	gold quality
adrenal tissue	UBERON:0018303	65.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.44	gold quality
amygdala	UBERON:0001876	64.69	gold quality
tibial artery	UBERON:0007610	64.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.66	gold quality
anterior cingulate cortex	UBERON:0009835	63.47	gold quality
caudate nucleus	UBERON:0001873	63.41	gold quality
putamen	UBERON:0001874	63.21	gold quality
left adrenal gland	UBERON:0001234	63.16	gold quality
urinary bladder	UBERON:0001255	63.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.04	gold quality
skin of abdomen	UBERON:0001416	62.97	gold quality
right ovary	UBERON:0002118	62.52	gold quality
esophagus mucosa	UBERON:0002469	62.38	gold quality
omental fat pad	UBERON:0010414	62.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.70	gold quality
left ovary	UBERON:0002119	61.66	gold quality
vagina	UBERON:0000996	61.59	gold quality
transverse colon	UBERON:0001157	61.36	gold quality
hypothalamus	UBERON:0001898	60.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.