MIR5008

Summary

MIR5008 (microRNA 5008, HGNC:43546) is a microRNA gene on chromosome 1q42.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847072 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43546
Approved symbol	MIR5008
Name	microRNA 5008
Location	1q42.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5008
Ensembl gene	ENSG00000264483
Ensembl biotype	miRNA
Entrez	100847072
RNAcentral	URS000075BDF8 — ncRNA, 94 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584300 — 1 exons

Exon	Start	End
ENSE00002714168	227941590	227941683

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 85.37.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	85.37	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.94	gold quality
blood	UBERON:0000178	78.99	gold quality
muscle of leg	UBERON:0001383	78.24	gold quality
gastrocnemius	UBERON:0001388	77.35	gold quality
placenta	UBERON:0001987	74.68	gold quality
stomach	UBERON:0000945	74.53	gold quality
islet of Langerhans	UBERON:0000006	74.35	gold quality
left adrenal gland cortex	UBERON:0035825	73.04	gold quality
lymph node	UBERON:0000029	71.92	gold quality
endometrium	UBERON:0001295	71.79	gold quality
body of stomach	UBERON:0001161	71.66	gold quality
heart left ventricle	UBERON:0002084	71.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.20	gold quality
calcaneal tendon	UBERON:0003701	71.18	gold quality
adrenal tissue	UBERON:0018303	71.09	gold quality
pancreas	UBERON:0001264	70.61	gold quality
descending thoracic aorta	UBERON:0002345	70.61	gold quality
adrenal gland	UBERON:0002369	70.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.54	gold quality
lower esophagus	UBERON:0013473	70.47	gold quality
ovary	UBERON:0000992	70.25	gold quality
left ovary	UBERON:0002119	70.08	gold quality
heart	UBERON:0000948	70.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.01	gold quality
esophagus	UBERON:0001043	69.86	gold quality
tibial artery	UBERON:0007610	69.83	gold quality
colon	UBERON:0001155	69.69	gold quality
right ovary	UBERON:0002118	69.66	gold quality
left adrenal gland	UBERON:0001234	69.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.