MIR500B

Summary

MIR500B (microRNA 500b, HGNC:38223) is a microRNA gene on chromosome Xp11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422911 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38223
Approved symbol	MIR500B
Name	microRNA 500b
Location	Xp11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-500b
Ensembl gene	ENSG00000239057
Ensembl biotype	miRNA
Entrez	100422911
RNAcentral	URS000075AD0A — miRNA, 79 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000458843

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458843 — 1 exons

Exon	Start	End
ENSE00001806954	50010672	50010750

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 95.66.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.66	gold quality
blood	UBERON:0000178	83.10	gold quality
colon	UBERON:0001155	80.72	gold quality
gastrocnemius	UBERON:0001388	72.59	gold quality
heart	UBERON:0000948	70.84	gold quality
stomach	UBERON:0000945	70.25	gold quality
adult mammalian kidney	UBERON:0000082	68.35	gold quality
body of stomach	UBERON:0001161	66.25	gold quality
skin of leg	UBERON:0001511	65.65	gold quality
thoracic mammary gland	UBERON:0005200	65.23	gold quality
omental fat pad	UBERON:0010414	65.14	gold quality
endometrium	UBERON:0001295	64.63	gold quality
skin of abdomen	UBERON:0001416	64.33	gold quality
caudate nucleus	UBERON:0001873	59.68	gold quality
metanephros cortex	UBERON:0010533	59.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (3): MIR500A (ENSG00000207785), MIR501 (ENSG00000211538), MIR502 (ENSG00000272080)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.