MIR5010

Summary

MIR5010 (microRNA 5010, HGNC:43484) is a microRNA gene on chromosome 17q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847046 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43484
Approved symbol	MIR5010
Name	microRNA 5010
Location	17q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5010
Ensembl gene	ENSG00000283929
Ensembl biotype	miRNA
Entrez	100847046
RNAcentral	URS000075B605 — ncRNA, 120 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582846

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582846 — 1 exons

Exon	Start	End
ENSE00002718356	42514188	42514307

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 89.87.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	89.87	gold quality
pituitary gland	UBERON:0000007	89.81	gold quality
adenohypophysis	UBERON:0002196	89.11	gold quality
skeletal muscle tissue	UBERON:0001134	88.04	gold quality
granulocyte	CL:0000094	87.13	gold quality
right ovary	UBERON:0002118	86.28	gold quality
mucosa of stomach	UBERON:0001199	84.02	gold quality
muscle of leg	UBERON:0001383	83.39	gold quality
gastrocnemius	UBERON:0001388	83.11	gold quality
blood	UBERON:0000178	82.93	gold quality
right lung	UBERON:0002167	82.82	gold quality
endometrium	UBERON:0001295	82.66	gold quality
ovary	UBERON:0000992	82.58	gold quality
descending thoracic aorta	UBERON:0002345	82.30	gold quality
left ovary	UBERON:0002119	82.28	gold quality
cortex of kidney	UBERON:0001225	82.01	gold quality
metanephros cortex	UBERON:0010533	81.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.82	gold quality
left uterine tube	UBERON:0001303	81.50	gold quality
right lobe of thyroid gland	UBERON:0001119	81.34	gold quality
transverse colon	UBERON:0001157	81.17	gold quality
skin of leg	UBERON:0001511	81.13	gold quality
body of uterus	UBERON:0009853	80.97	gold quality
zone of skin	UBERON:0000014	80.88	gold quality
spleen	UBERON:0002106	80.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.74	gold quality
skin of abdomen	UBERON:0001416	80.69	gold quality
right coronary artery	UBERON:0001625	80.55	gold quality
small intestine	UBERON:0002108	80.46	gold quality
left lobe of thyroid gland	UBERON:0001120	80.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-5010-5p ameliorates high-glucose induced inflammation in renal tubular epithelial cells by modulating the expression of PPP2R2D. (PMID:38442987)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.