MIR503HG

Summary

MIR503HG (MIR503 host gene, HGNC:28258) is a long non-coding RNA gene on chromosome Xq26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28258
Approved symbol	MIR503HG
Name	MIR503 host gene
Location	Xq26.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC16121, H19X
Ensembl gene	ENSG00000223749
Ensembl biotype	lncRNA
Entrez	84848
RNAcentral	URS000075CE3A — lncRNA, 786 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000414769, ENST00000440570, ENST00000441492, ENST00000445415, ENST00000457876, ENST00000655068, ENST00000659680, ENST00000666697, ENST00000670930, ENST00000673627, ENST00000809845, ENST00000809846, ENST00000809847, ENST00000809848, ENST00000809849, ENST00000809850, ENST00000809851, ENST00000809852, ENST00000809853, ENST00000809854, ENST00000809855, ENST00000809856, ENST00000809857

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414769 — 4 exons

Exon	Start	End
ENSE00001725296	134544714	134544797
ENSE00004206079	134543119	134543999
ENSE00004206096	134548476	134548530
ENSE00004206108	134546552	134546743

Expression profiles

Bgee: expression breadth ubiquitous, 180 present calls, max score 97.91.

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	97.91	gold quality
left uterine tube	UBERON:0001303	97.57	gold quality
right ovary	UBERON:0002118	96.19	gold quality
left ovary	UBERON:0002119	96.04	gold quality
pituitary gland	UBERON:0000007	94.87	gold quality
placenta	UBERON:0001987	94.68	gold quality
adenohypophysis	UBERON:0002196	94.30	gold quality
adrenal tissue	UBERON:0018303	93.98	gold quality
endocervix	UBERON:0000458	93.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.12	gold quality
right uterine tube	UBERON:0001302	92.74	gold quality
right testis	UBERON:0004534	92.49	gold quality
left testis	UBERON:0004533	91.68	gold quality
ovary	UBERON:0000992	91.60	gold quality
metanephros	UBERON:0000081	91.25	gold quality
testis	UBERON:0000473	90.62	gold quality
pancreatic ductal cell	CL:0002079	89.59	gold quality
metanephros cortex	UBERON:0010533	88.97	gold quality
ectocervix	UBERON:0012249	88.86	gold quality
fallopian tube	UBERON:0003889	88.04	gold quality
body of uterus	UBERON:0009853	87.69	gold quality
spleen	UBERON:0002106	86.60	gold quality
uterine cervix	UBERON:0000002	86.53	gold quality
tibialis anterior	UBERON:0001385	85.50	silver quality
kidney epithelium	UBERON:0004819	85.29	silver quality
female reproductive system	UBERON:0000474	84.79	gold quality
adult mammalian kidney	UBERON:0000082	84.28	gold quality
myometrium	UBERON:0001296	84.24	gold quality
uterus	UBERON:0000995	83.87	gold quality
right lobe of thyroid gland	UBERON:0001119	83.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• lincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis. (PMID:27023770)
• The current study showed that MIR503HG enhances the growth ability of ALK-negative ALCL by protecting and activating components of the miR-503/Smuf2/ TGFBR pathway. (PMID:29758012)
• Long non-coding RNA MIR503HG functions as a tumor suppressor and inhibits cell proliferation, metastasis and epithelial-mesenchymal transition in bladder cancer. (PMID:30672010)
• LncRNA MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer. (PMID:31062436)
• Low MIR503HG expression is associated with colorectal cancer. (PMID:31278965)
• MIR503HG inhibited the proliferation, invasion, and migration of HTR-8/SVneo and JEG3 cells via regulating matrix metalloproteinases and NF-kB signaling. (PMID:31467616)
• Long non-coding RNA MIR503HG serves as a tumor suppressor in non-small cell lung cancer mediated by wnt1. (PMID:31858550)
• Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p. (PMID:31983569)
• Structure and expression of the long noncoding RNA gene MIR503 in humans and non-human primates. (PMID:32311422)
• MiR-503-5p functions as an oncogene in oral squamous cell carcinoma by targeting Smad7. (PMID:32319077)
• Long non-coding RNA MIR503HG inhibits the proliferation, migration and invasion of colon cancer cells via miR-107/Par4 axis. (PMID:32738347)
• MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. (PMID:33703914)
• LncRNA MIR503HG promotes hypertrophic scar progression via miR-143-3p-mediated Smad3 expression. (PMID:33819360)
• LncRNA MIR503HG regulated cell viability, metastasis and apoptosis of cervical cancer via miR-191/CEBPB axis. (PMID:33928605)
• Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. (PMID:33932142)
• Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-kappaB/NLRP3 Inflammasome Pathway. (PMID:35707534)
• MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription. (PMID:35771155)
• [MIR503HG promotes esophageal squamous cell carcinoma cell proliferation, invasion and migration via hsa-miR-503 pathway]. (PMID:36380664)
• MIR503HG: A potential diagnostic and therapeutic target in human diseases. (PMID:36736276)
• lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm. (PMID:37228901)
• Loss of MIR503HG facilitates papillary renal cell carcinoma associated lymphatic metastasis by triggering NOTCH1/VEGFC signaling. (PMID:37416763)
• LINC MIR503HG Controls SC-beta Cell Differentiation and Insulin Production by Targeting CDH1 and HES1. (PMID:38243869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.