MIR504

Summary

MIR504 (microRNA 504, HGNC:32139) is a microRNA gene on chromosome Xq26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574507 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32139
Approved symbol	MIR504
Name	microRNA 504
Location	Xq26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-504
Ensembl gene	ENSG00000207800
Ensembl biotype	miRNA
Entrez	574507
RNAcentral	URS00006F1C02 — miRNA, 83 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385065

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385065 — 1 exons

Exon	Start	End
ENSE00001500071	138667711	138667793

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 81.10.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.10	gold quality
stomach	UBERON:0000945	77.99	gold quality
heart	UBERON:0000948	76.13	gold quality
putamen	UBERON:0001874	71.99	gold quality
gastrocnemius	UBERON:0001388	71.73	gold quality
left adrenal gland cortex	UBERON:0035825	71.07	gold quality
transverse colon	UBERON:0001157	69.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.44	gold quality
vagina	UBERON:0000996	63.71	gold quality
amygdala	UBERON:0001876	63.21	gold quality
esophagus mucosa	UBERON:0002469	62.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• Results demonstrate the direct negative regulation of p53 by miR-504 as a mechanism for p53 regulation in cells, which highlights the importance of microRNAs in tumorigenesis. (PMID:20542001)
• A reverse correlation between CTGF and miR-504, miR-504 and FOXP1, and a positive correlation between CTGF and FOXP1 were shown. (PMID:21927029)
• Upregulation of miR-504 is associated with primary glioblastoma. (PMID:22844109)
• Data shows that loss of tumor-suppressive miR-504 enhanced of hypopharyngeal squamous cell carcinoma proliferation through targeting CDK6. (PMID:24647829)
• Loss of Klotho protein expression, klotho promoter hypermethylation, high miR-504 levels, and high phospho-IGF-1R levels significantly correlated with poor survival, high clinical and pathological stages in pancreatic ductal adenocarcinoma patients (PMID:24745611)
• Western blot analysis data demonstrated that miR-504 abrogates TFF1-induced p53 protein expression and activity. (PMID:25015107)
• Our results suggest that miR-504 may be a prognostic predictor and be involved in tumorigencity as a tumor suppressor of malignant glioma. (PMID:25755767)
• High miR-504 expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma. (PMID:26201446)
• post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7, miR-34a, and miR-504, is reported. (PMID:26572867)
• Data demonstrated that miR-504 regulated glioma tumorigenesis by downregulating FOXP1 expression. Results suggest that miR-504 might function as an important suppressor of glioma tumorigenesis. (PMID:26854715)
• Only miR-504 serum expression can be utilized as reliable differential diagnosis marker. (PMID:28534372)
• These results revealed the antiapoptotic role of miRNA504 in vascular smooth muscle cells derived from patients with abdominal aortic aneurysm via direct targeting of p53. (PMID:28677789)
• these results revealed that TP53INP1 is a target gene of miR-504 and that miR-504 enhances osteosarcoma growth and promotes distant metastases by targeting TP53INP1. Thus, miR-504/TP53INP1 may be associated with osteosarcoma size and clinical stage. (PMID:29048685)
• Our results indicated that miR-504 functioned as a tumor suppressor in non small cell lung cancer (PMID:29156517)
• miR-504-meidated FZD7/Wnt/beta-catenin signaling pathway plays an important role in hepatocellular carcinoma development. (PMID:30142536)
• these results indicated a significant role of the miR504/AEG1 pathway in inhibiting the aggressiveness of RB, suggesting that this miRNA may be employed as a therapeutic target for the treatment of patients with this disease. (PMID:30720088)
• Low miR504 expression is associated with glioblastoma. (PMID:31419987)
• In human squamous cell carcinoma cell lines miR-504 functions as tumor suppressor gene through inhibiting cell proliferation, migration and invasion by targeting CDK6. In a Chinese hamster oral squamous cell carcinoma animal model, miR-504 expression is down regulated in tumor tissues. (PMID:31812760)
• Silencing of miR-504 partly abrogated ROR1-AS1 knockdown-induced inhibitory effects on bladder cancer cell growth and migration. (PMID:31929567)
• miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles. (PMID:33093452)
• miR-504 Promoted Gastric Cancer Cell Proliferation and Inhibited Cell Apoptosis by Targeting RBM4. (PMID:34195294)
• MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells. (PMID:36027039)
• miR-504 knockout regulates tumor cell proliferation and immune cell infiltration to accelerate oral cancer development. (PMID:38871233)
• LncRNA ILF3-AS1 mediates oxidative stress and inflammation through miR-504-3p/HMGB1 axis in a cellular model of temporal lobe epilepsy. (PMID:39135276)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir504	ENSMUSG00000070110

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.