MIR507

Summary

MIR507 (microRNA 507, HGNC:32144) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574512 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32144
Approved symbol	MIR507
Name	microRNA 507
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-507
Ensembl gene	ENSG00000207969
Ensembl biotype	miRNA
Entrez	574512
RNAcentral	URS000075B543 — miRNA, 94 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385234

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385234 — 1 exons

Exon	Start	End
ENSE00001500240	147230984	147231077

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 84.66.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	84.66	gold quality
kidney	UBERON:0002113	82.44	gold quality
skin of abdomen	UBERON:0001416	76.10	gold quality
monocyte	CL:0000576	73.69	gold quality
blood	UBERON:0000178	73.63	gold quality
right atrium auricular region	UBERON:0006631	72.23	gold quality
gall bladder	UBERON:0002110	72.13	gold quality
gastrocnemius	UBERON:0001388	71.65	gold quality
heart	UBERON:0000948	71.51	gold quality
ascending aorta	UBERON:0001496	70.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.45	gold quality
liver	UBERON:0002107	69.52	gold quality
right lobe of liver	UBERON:0001114	69.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.32	gold quality
esophagus mucosa	UBERON:0002469	68.13	gold quality
intestine	UBERON:0000160	67.75	gold quality
colon	UBERON:0001155	67.75	gold quality
spleen	UBERON:0002106	67.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.17	gold quality
tibial artery	UBERON:0007610	66.60	gold quality
transverse colon	UBERON:0001157	66.09	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.78	gold quality
right frontal lobe	UBERON:0002810	65.72	gold quality
corpus callosum	UBERON:0002336	65.49	gold quality
frontal cortex	UBERON:0001870	65.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.88	gold quality
mucosa of transverse colon	UBERON:0004991	64.81	gold quality
putamen	UBERON:0001874	64.72	gold quality
vagina	UBERON:0000996	64.09	gold quality
body of stomach	UBERON:0001161	63.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Results indicate that miR-507 represented potential therapeutic targets in breast cancer by modulating fms-related tyrosine kinase-1 (Flt-1). (PMID:27167339)
• we discovered a novel mechanism through which UCA1 regulated miR-507 in melanoma (PMID:27389544)
• LINC00243 modulated expression of endogenous miR-507-targeted PDK4. LINC00243 promotes proliferation and glycolysis in NSCLC cells by positively regulating PDK4 through sponging miR-507. (PMID:31595421)
• MicroRNA-507 represses the malignant behaviors of non-small cell lung cancer via targeting zinc finger E-box binding homeobox 2. (PMID:31799665)
• MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4. (PMID:32572897)
• MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/beta-catenin and HIF-1alpha pathways. (PMID:35819589)
• Knockdown of circLRWD1 weakens DDP resistance via reduction of SIRT5 expression through releasing miR-507 in non-small cell lung cancer. (PMID:35946561)

Cross-species orthologs

0 orthologs

Paralogs (9): MIR506 (ENSG00000207731), MIR514A2 (ENSG00000207866), MIR514A3 (ENSG00000207867), MIR514A1 (ENSG00000207868), MIR513B (ENSG00000207871), MIR513A2 (ENSG00000207984), MIR509-1 (ENSG00000208000), MIR509-3 (ENSG00000212014), MIR514B (ENSG00000252583)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.