MIR508

Summary

MIR508 (microRNA 508, HGNC:32145) is a microRNA gene on chromosome Xq27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574513 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32145
Approved symbol	MIR508
Name	microRNA 508
Location	Xq27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-508
Ensembl gene	ENSG00000207589
Ensembl biotype	miRNA
OMIM	300874
Entrez	574513
RNAcentral	URS000075C79A — miRNA, 115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384857

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384857 — 1 exons

Exon	Start	End
ENSE00001499864	147236913	147237027

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 85.90.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.90	gold quality
muscle of leg	UBERON:0001383	85.39	gold quality
adult mammalian kidney	UBERON:0000082	80.67	gold quality
monocyte	CL:0000576	78.94	gold quality
stomach	UBERON:0000945	72.76	gold quality
endometrium	UBERON:0001295	70.65	gold quality
colon	UBERON:0001155	69.75	gold quality
intestine	UBERON:0000160	69.55	gold quality
esophagus mucosa	UBERON:0002469	69.20	gold quality
transverse colon	UBERON:0001157	68.81	gold quality
Ammon’s horn	UBERON:0001954	68.59	gold quality
liver	UBERON:0002107	66.80	gold quality
small intestine	UBERON:0002108	66.66	gold quality
right frontal lobe	UBERON:0002810	65.71	gold quality
right lobe of liver	UBERON:0001114	65.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.53	gold quality
metanephros cortex	UBERON:0010533	64.48	gold quality
skin of leg	UBERON:0001511	62.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.06	gold quality
nucleus accumbens	UBERON:0001882	59.75	gold quality
corpus callosum	UBERON:0002336	57.51	gold quality
left testis	UBERON:0004533	45.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC. (PMID:22369946)
• The miRNAs miR-126 and miR-508-5p are associated with the outcome of ICM and NICM patients with CHF. (PMID:23465244)
• A miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer. (PMID:23893241)
• miR-508 has a role in sustaining phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma by suppressing INPP5J (PMID:25099196)
• Data show that the miR-27b/cyclin G1 protein (CCNG1)/p53 tumor suppressor protein (P53)/miR-508-5p axis plays important roles in gastric cancer (GC)-associated multidrug resistance (MDR). (PMID:26623719)
• canonical NF-kappaB signaling pathway is activated in gastric cancer at least by the inactivation of miR-508-3p. (PMID:26801246)
• Increased expression of miR-508-5p inhibits the progression of glioma. (PMID:27003587)
• miR-508-5p acts as a tumor suppressor by targeting MESDC1 in hepatocellular carcinoma progression. (PMID:27881003)
• miR-508-5p was downregulated in glioma tissues and cell lines; high expression level of miR-508-5 was correlated with reduced survival of glioma patients; cell experiments revealed that overexpression of miR-508-5 suppresses glioma cell proliferation and migration (PMID:28121353)
• The overexpression of miR5085p was able to downregulate the expression of the SKP2 oncogene, through a mechanism by which miR5085p directly targeted the SKP2 gene. (PMID:28627698)
• miR-508 simultaneously and directly targets multiple epithelial-to-mesenchymal transition and stemness genes including ZEB1, BMI1, and SALL4, and inhibits the colorectal cancer epithelial-to-mesenchymal transition and stemness process. (PMID:29374066)
• miR-508 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of ovarian cancer cells via the MAPK1/ERK signaling pathway. (PMID:29781537)
• MiR-508-3p significantly suppressed tumor cell epithelial mesenchymal transformation by regulating ZEB1 expression in triple-negative breast cancer. (PMID:30338806)
• A multidimensional network analysis identified miR-508-3p as a master regulator that defines the mesenchymal subtype and provides a novel prognostic biomarker to improve management of ovarian cancer. (PMID:30478449)
• Study demonstrated that miR-508-5p regulated the osteogenesis of hDPCs by targeting GPNMB and provided novel insight into the critical roles of microRNAs in hDPC differentiation. (PMID:30670091)
• The current study demonstrates that the SLCO4A1-AS1/miR-508-3p/PARD3/autophagy pathway play a critical role in colorectal cancer cell proliferatio (PMID:31308265)
• Knock-down of Long non-coding RNA Linc00483 inhibited the development of cervical cancer by regulating miR-508-3p/RGS17 axis. (PMID:31454494)
• miR-508-3p and miR-885-5p were found to be significantly dysregulated in ccRCC tissues and the serum of ccRCC patients. (PMID:31661117)
• miR5083p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7. (PMID:32377701)
• ZNF295-AS1 inhibits autophagy via the ZNF295-AS1/miR-508-5p/ATG7 axis in AS. (PMID:32633396)
• A Potential Tumor Suppressor Gene Named miR-508-5p Inhibited the Proliferation and Invasion of Human Melanoma Cells by Targeting KIT. (PMID:33000689)
• Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis. (PMID:33082297)
• Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression. (PMID:33344634)
• LncRNA PCAT-1 promotes the progression of osteosarcoma via miR-508-3p/ZEB1 axis. (PMID:33829438)
• LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma. (PMID:33829443)
• miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia. (PMID:34147937)
• MiR-508-3p promotes proliferation and inhibits apoptosis of middle ear cholesteatoma cells by targeting PTEN/PI3K/AKT pathway. (PMID:34400892)
• Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p. (PMID:34483137)
• Circ_FOXP1 promotes the growth and survival of high glucose-treated human trophoblast cells through the regulation of miR-508-3p/SMAD family member 2 pathway. (PMID:35545535)
• Hsa_circ_0002082 up-regulates Centromere Protein F via abolishing miR-508-3p to promote breast cancer progression. (PMID:36161346)
• CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression. (PMID:36729852)
• miR-508-5p serves as an anti-oncogene by targeting S100A16 to regulate AKT signaling and epithelial-mesenchymal transition process in lung adenocarcinoma cells. (PMID:36967030)
• Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis. (PMID:37212178)
• Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1. (PMID:38081797)
• MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein. (PMID:38099479)
• Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway. (PMID:38150791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.