MIR5087

Summary

MIR5087 (microRNA 5087, HGNC:43480) is a microRNA gene on chromosome 1q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847044 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43480
Approved symbol	MIR5087
Name	microRNA 5087
Location	1q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5087
Ensembl gene	ENSG00000283676
Ensembl biotype	miRNA
Entrez	100847044
RNAcentral	URS000075A565 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635826

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635826 — 1 exons

Exon	Start	End
ENSE00003794350	148334479	148334554

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 97.90.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.90	gold quality
right uterine tube	UBERON:0001302	91.02	gold quality
calcaneal tendon	UBERON:0003701	84.44	gold quality
vermiform appendix	UBERON:0001154	81.76	gold quality
bone marrow	UBERON:0002371	81.46	gold quality
adrenal tissue	UBERON:0018303	79.10	gold quality
placenta	UBERON:0001987	78.78	gold quality
granulocyte	CL:0000094	77.48	gold quality
amygdala	UBERON:0001876	77.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.06	gold quality
anterior cingulate cortex	UBERON:0009835	76.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.70	gold quality
fallopian tube	UBERON:0003889	76.69	gold quality
right coronary artery	UBERON:0001625	76.08	gold quality
cerebral cortex	UBERON:0000956	75.70	gold quality
monocyte	CL:0000576	75.46	gold quality
rectum	UBERON:0001052	74.85	gold quality
frontal cortex	UBERON:0001870	74.78	gold quality
right frontal lobe	UBERON:0002810	74.60	gold quality
blood	UBERON:0000178	73.65	gold quality
prefrontal cortex	UBERON:0000451	73.51	gold quality
endometrium	UBERON:0001295	73.43	gold quality
kidney	UBERON:0002113	73.41	gold quality
substantia nigra	UBERON:0002038	73.26	gold quality
gall bladder	UBERON:0002110	73.03	gold quality
Ammon’s horn	UBERON:0001954	72.88	gold quality
brain	UBERON:0000955	72.67	gold quality
hypothalamus	UBERON:0001898	72.58	gold quality
gastrocnemius	UBERON:0001388	72.40	gold quality
lymph node	UBERON:0000029	72.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.87

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.