MIR5088

Summary

MIR5088 (microRNA 5088, HGNC:43489) is a microRNA gene on chromosome 19q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847074 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43489
Approved symbol	MIR5088
Name	microRNA 5088
Location	19q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5088
Ensembl gene	ENSG00000274306
Ensembl biotype	miRNA
Entrez	100847074
RNAcentral	URS000075A259 — ncRNA, 79 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615402

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615402 — 1 exons

Exon	Start	End
ENSE00003734044	49682117	49682195

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 83.50.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	83.50	gold quality
monocyte	CL:0000576	75.58	gold quality
stomach	UBERON:0000945	72.99	gold quality
blood	UBERON:0000178	72.68	gold quality
anterior cingulate cortex	UBERON:0009835	70.11	gold quality
adrenal gland	UBERON:0002369	69.19	gold quality
caudate nucleus	UBERON:0001873	68.67	gold quality
right adrenal gland	UBERON:0001233	67.87	gold quality
right atrium auricular region	UBERON:0006631	67.87	gold quality
right frontal lobe	UBERON:0002810	67.71	gold quality
heart left ventricle	UBERON:0002084	66.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.15	gold quality
myometrium	UBERON:0001296	65.69	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.35	gold quality
prostate gland	UBERON:0002367	65.23	gold quality
omental fat pad	UBERON:0010414	65.12	gold quality
tibial artery	UBERON:0007610	65.09	gold quality
vagina	UBERON:0000996	65.05	gold quality
right lobe of liver	UBERON:0001114	64.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.97	gold quality
skin of abdomen	UBERON:0001416	63.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.29	gold quality
putamen	UBERON:0001874	63.01	gold quality
esophagus mucosa	UBERON:0002469	62.62	gold quality
skin of leg	UBERON:0001511	62.50	gold quality
Ammon’s horn	UBERON:0001954	62.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.87	gold quality
transverse colon	UBERON:0001157	61.84	gold quality
left adrenal gland	UBERON:0001234	61.51	gold quality
spleen	UBERON:0002106	61.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Analysis of the subcellular location of lncRNA SLC16A1-AS1 and its interaction with premature miR-5088-5p in oral squamous cell carcinoma. (PMID:35829849)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.