MIR5089

Summary

MIR5089 (microRNA 5089, HGNC:43536) is a microRNA gene on chromosome 17q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847067 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43536
Approved symbol	MIR5089
Name	microRNA 5089
Location	17q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5089
Ensembl gene	ENSG00000264999
Ensembl biotype	miRNA
Entrez	100847067
RNAcentral	URS000075BE9A — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580047

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580047 — 1 exons

Exon	Start	End
ENSE00002703667	46973017	46973100

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 78.11.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	78.11	gold quality
calcaneal tendon	UBERON:0003701	76.67	gold quality
monocyte	CL:0000576	75.54	gold quality
gastrocnemius	UBERON:0001388	74.48	gold quality
blood	UBERON:0000178	73.36	gold quality
adrenal gland	UBERON:0002369	70.06	gold quality
endometrium	UBERON:0001295	69.45	gold quality
body of pancreas	UBERON:0001150	69.24	gold quality
left adrenal gland	UBERON:0001234	68.79	gold quality
granulocyte	CL:0000094	68.47	gold quality
heart left ventricle	UBERON:0002084	68.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.36	gold quality
myometrium	UBERON:0001296	66.93	gold quality
tibial artery	UBERON:0007610	66.80	gold quality
popliteal artery	UBERON:0002250	66.74	gold quality
anterior cingulate cortex	UBERON:0009835	66.72	gold quality
thoracic aorta	UBERON:0001515	66.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.50	gold quality
amygdala	UBERON:0001876	66.31	gold quality
body of stomach	UBERON:0001161	65.97	gold quality
ascending aorta	UBERON:0001496	65.95	gold quality
left coronary artery	UBERON:0001626	65.65	gold quality
right atrium auricular region	UBERON:0006631	65.47	gold quality
right frontal lobe	UBERON:0002810	65.39	gold quality
putamen	UBERON:0001874	65.16	gold quality
transverse colon	UBERON:0001157	64.98	gold quality
cerebral cortex	UBERON:0000956	64.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.